The pharmacokinetics of sulfamethoxazole and trimethoprim are similar to nonpregnant values in early pregnancy (Ylikorkala 1973). Sulfamethoxazole and trimethoprim are recommended for the prophylaxis or treatment of Pneumocystis jirovecii pneumonia (PCP), prophylaxis of Toxoplasmic gondii encephalitis (TE),...
When sulfamethoxazole and trimethoprim tablets are prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of ...
Trimethoprim/sulfamethoxazole should be used during pregnancy only if potential maternal benefits outweigh potential risks to the fetus. Trimethoprim/sulfamethoxazole is present in breastmilk. There is no information on the drug’s effects on milk production or the breastfed infant. Breastfeeding should ...
It is contraindicated?to use trimethoprim during pregnancy, especially the first trimester, and for sufferers of certain blood disorders. 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine (CAS NO.738-70-5) also?may be involved in a reaction similar to disulfiram when alcohol is consumed after...
(e.g., the common cold). When sulfamethoxazole and trimethoprim tablets are prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not ...
Large doses or long term therapy may interfere with hematopoiesis; the presence of clinical signs, such as sore throat, fever, pallor, or purpura may be early indications of serious blood disorders; monitor for signs/symptoms of hematologic disorders If clinical signs of blood disorder noted, ...
Trimethoprim use in early pregnancy and the risk of miscarriage: a register-based nationwide cohort study. Epidemiol Infect. 2013;141(8):1749–55. https://doi.org/10.1017/S0950268812002178. Article PubMed CAS Google Scholar Food and Drug Administration HHS. Requirements on content and format of...
particularly neural tube defects, cardiovascular malformations, urinary tract defects, oral clefts, and club foot. If sulfamethoxazole and trimethoprim is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be advised of the potential hazards to the fet...
When sulfamethoxazole and trimethoprim oral suspension is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full ...
• Pregnancy at term or when premature birth is possible • Infants younger than 2 months (except inP. jirovecipneumonia prophylaxis) Precautions Use cautiously in: • urinary obstruction, renal or hepatic disease, bronchial asthma, G6PD deficiency, group A beta-hemolytic streptococcal infection,...