Protein depletion is a key approach to understanding the functions of a protein in a biological system. We recently developed the Trim-Away approach in order to rapidly degrade endogenous proteins without prior modification. Trim-Away is based on the ubi
The cytosolic antibody receptor TRIM21 possesses unique ubiquitination activity that drives broad-spectrum anti-pathogen targeting and underpins the protein depletion technology Trim-Away. This activity is dependent on formation of self-anchored, K63-linked ubiquitin chains by the heterodimeric E2 enzyme ...
Define Trimera. Trimera synonyms, Trimera pronunciation, Trimera translation, English dictionary definition of Trimera. n. pl. 1. A division of Coleoptera including those which have but three joints in the tarsi. Webster's Revised Unabridged Dictionary,
Our last consideration was to test whether the operation of TRIM21-mediated protein depletion through our microinjection protocol can, in principle, operate selectively in the mouse developmental environment and also preserve developmental ability. To stringently test the selectivity of the TRIM21 reaction...
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I'm trying to analyze a set of Paired FastQ files with dada2 in R. In my analysis I was doing before I realized that the raw reads still had their primers attached. So I went through the ITS workflow to remove my primers. But I'm limited...
KHC1179 is a ready-to-use IHC kit for staining of TRIM32. The kit provides all reagents, from antigen retrieval to cover slip mounting, that require little to no diluting or handling prior to use. Simply apply the reagents to your sample slide according
ObservableStreamPlugin isn't used and should be trimmed away when you don't use ReflectionBinding (which is enabled by default). If you use compiled bindings only, you are safe. But it seems ObservableStreamPlugin type is referenced somewhere somehow keeping it in assembly still, causing these...
Simply apply the reagents to your sample slide according to the protocol and you're steps away from obtaining high-quality IHC data. Product name IHCeasy TRIM63 Ready-To-Use IHC Kit Sample type FFPE tissue Assay type Immunohistochemistry Primary antibody type Rabbit Polyclonal Secondary antibody ...
Conaway2,4 & Shigetsugu Hatakeyama1 Although DNA double-strand break (DSB) repair is mediated by numerous proteins accu- mulated at DSB sites, how DNA repair proteins are assembled into damaged chromatin has not been fully elucidated. Here we show that a member of the tripartite motif ...