Triiodothyronine (T3) is secreted by the thyroid and is the major active product formed from thyroxine (T4) in the tissues under the influence of microsomal deiodinase enzymes, which remove the iodine from the "outer" ring of thyroxine (5'-deiodination). It activates nuclear thyroid hormone ...
n.Abbr.T3 An iodine-containing hormone, C15H12I3NO4, produced by the thyroid gland and similar to but more potent than thyroxine. A synthetic form (liothyronine) is used in the treatment of hypothyroidism. [tri-+iodo-+thyronine,an amino acid(thyr(o)-+-on(e)+-ine).] ...
While 3, 3', 5'-triiodothyronine (reverse T3, rT3) has been detected both in human serum and in thyroglobulin, no quantitative assessment of its metabolic clearance rate (MCR), production rate (PR), or secretion by the thyroid is yet ava... IJ Chopra - 《Journal of Clinical Investigation...
3,3′,5′-Triiodothyronine (Reverse T3, rT3) rT3is secreted in very small amounts by thethyroid glandbut its plasma concentration essentially reflects T4 degradation of which it is a product. rT3 concentrations tend to be elevated in circumstances where T3 is low in the absence of clinical hy...
In light of the fact that systemic administration of the pharmacological dose of TH causes multiple deleterious effects on several non-adipose tissues and also impair thermogenesis in BAT, we investigated whether the selective delivery of T3 to adipose tissue is sufficient to mimic its metabolic benef...
SUMMARYAt present it is widely assumed that T3 derived from T4 is rapidly and totally exchangeable within the volume of distribution of T3 secreted by the thyroid into the bloodstream. This concept is implied when conclusions are drawn from comparisons between a biological effect in a responsive ...
n.Abbr.T3 An iodine-containing hormone, C15H12I3NO4, produced by the thyroid gland and similar to but more potent than thyroxine. A synthetic form (liothyronine) is used in the treatment of hypothyroidism. [tri-+iodo-+thyronine,an amino acid(thyr(o)-+-on(e)+-ine).] ...
T3VEGFLeydig cells are the principal steroidogenic cells of the testis. Leydig cells also secrete a number of growth factors including vascular endothelial growth factor (VEGF) which has been shown to regulate both testicular steroidogenesis and spermatogenesis. The thyroid hormone, T 3, is known to...
3,3′,5′-Triiodothyronine (Reverse T3, rT3) rT3is secreted in very small amounts by the thyroid gland but itsplasma concentrationessentially reflects T4 degradation of which it is a product. rT3 concentrations tend to be elevated in circumstances where T3 is low in theabsenceof clinical hypoth...
(MCT8), a specific TH transporter [8]. In addition, the intracellular level of T3 is controlled by deiodinases [9]. Specifically, in the disease state, the activity of Dio3 increases to convert excess T3 into diiodothyronine (T2) and prevent the further generation of T3 [5]. Even ...