For pharmacological inhibition of Atgl, mice were randomly selected to be fed a HFD or chow diet supplemented with 2 mmol kg−1 Atglistatin18. Before Atglistatin-HFD treatment, mice were fed a HFD without Atglistatin for 50 days unless otherwise stated....
Provision of a balanced diet containing 28.5% of the total calories as triacetin had no adverse effects on metabolic substrates and resulted in smaller and more numerous mucosal cells in the jejunum and colon. These data indicate that the short-chain triglyceride triacetin could aid in the ...
Loss of PNPLA3 aggravates hepatic steatosis while lowering plasma TG in response to a PUFA-enriched lipogenic diet To determine the liver-specific function of PNPLA3 in vivo, we gener- ated PNPLA3-floxed (PNPLA3fl/fl) mice (Supplementary Fig. 2a). At 8–10 weeks of age, these mice ...