Background & Aims: Cerebral oxidative stress plays an important role in the pathogenesis of hepatic encephalopathy (HE), but the underlying mechanisms are incompletely understood. Herein, we analyzed a role of heme oxygenase (HO)1, iron and NADPH oxidase 4 (Nox4) for the induction of oxidative...
The contribution of Dopamine (DA) to minimal hepatic encephalopathy (MHE) has been demonstrated. However, recent studies have revealed that cholesterol (CHO) treatment substantially increased the risk of dementia. The objectives of this study were to investigate whether CHO was induced by DA over...
586 RENAL NKCC2 TRANSPORTER TRIGGERS ENHANCED URINARY AMMONIA EXCRETION DURING INDUCED HYPERAMMONEMIA: A NOVEL TARGET OF THERAPY FOR HEPATIC ENCEPHALOPATHY?Publication » 586 RENAL NKCC2 TRANSPORTER TRIGGERS ENHANCED URINARY AMMONIA EXCRETION DURING INDUCED HYPERAMMONEMIA: A NOVEL TARGET OF THERAPY FOR ...
Accumulation of ammonium and glutamine in blood and brain is a key factor in hepatic encephalopathy (HE) - a neuropsychiatric syndrome characterized by various cognitive and motor deficits. MRI imaging identified abnormalities notably in the basal ganglia of HE patients, including its major input ...