In order to analyse mitotic progression and chromosome behaviour shortly after expression of KRASG12D, we stably integrated GFP-tagged histone H2B into HeLaG12D cells, and performed time-lapse imaging 24 h after addition of doxycycline. As shown in Fig. 1c, untreated cells spent an ...
The United States has a long history of private-sector involvement in surface transportation infrastructure, dating back to the Philadelphia and Lancaster Turnpike in 1795 (Dempsey 2003). However, ...
Cell–cell fusion therefore contributes to genome doubling and reshuffling, leading to emergence of hybrids with a unique behaviour pattern. Mechanisms as chromothripsis or cytokinesis errors produce genome remodelling in a single event as well, a leap during tumour evolution called macroevolutionary ...
STIM1 is an endoplasmic reticulum protein with a role in Ca2+ mobilization and signaling. As a sensor of intraluminal Ca2+ levels, STIM1 modulates plasma m
Thanks for challenging us to stretch beyond our comfort zone! Reply Skylor After I read this, I wiped out 3 of my programs that haven’t made money in about a year. What a relief! Thank you for the permission! Reply Shawn Hey Derick, one thing that you don’t share is how ar...
The representations of heroes and the heroic acts point to social values, norms, and morality of the present, creating a bridge between the past and a pote