Published in the series MAK Value Documentations , Vol. 24 (2007) The article contains sections titled: Effects in Humans Effects on the CNS Renal toxicity Renal carcinogenicity Glutathione conjugation of trichloroethylene in test persons and in vitro Genotoxicity Animal Experiments and in vitro ...
None of these effects are seen in rats due to metabolic and pharmacokinetic differences nor can they be replicated in human tissues. The low incidences of rat kidney tumours seen in some cancer bioassays appear to be linked to high dose toxicity. Human epidemiology studies based on large well ...
Two of these, DCA and CHL, are used therapeutically in humans, while a third, TCA, has metabolic effects similar to compounds used therapeutically in humans to reduce lipid concentrations in blood. Each of these three compounds produces biological responses that are expected in humans. However, ...
The impact of cytochrome P450 2E1-dependent metabolic variance on a risk-relevant pharmacokinetic outcome in humans. Risk assessments include assumptions about sensitive subpopulations, such as the fraction of the general population that is sensitive and the extent that b... JC Lipscomb,LK Teuschler...
Interindividual variability in the disposition and effects of xenobiotics in humans and related inter-species differences should play a major role in human risk assessment. In particular for low-dose exposures to potentially carcinogenic compounds, novel tools and concepts are necessary to assess risks ...
Administration of TCE in the diet of mice and rats at concentrations equivalent to doses of up to 300 mg/kg bw per day for two generations resulted in marginal effects on testicular weight and on survival of pups of both the F1 and F2 generations at the highest dose. In general, TCE ...
Evaluation of the psychophysiological functions in humans exposed to trichloroethylene. To provide data on the psychophysiological efficiency of human beings exposed to solvent vapour currently used in the industry the effects of trichloroethylene (TCE) were evaluated by exposing six male university students...
Exposure to the environmental pollutant trichloroethylene (TCE) has been linked to autoimmune disease development in humans. Chronic (32-week) low-level exposure to TCE has been shown to promote autoimmune hepatitis in association with CD4(+) T cell activation in autoimmune-prone MRL+/+ mice. MRL...
and epidemiological studies on lead-exposed workers suggest that lead has an ototoxic effect caused by a neurotoxic mechanism.130–134Similarly, mercury compounds were shown to induce hearing-damaging effects both in laboratory animals (methyl mercury chloride and mercuric sulfide) and humans.135–138...
Health Hazard The toxic effects manifested in humansfrom inhaling trichloroethylene vapors areheadache, dizziness, drowsiness, fatigue, andvisual disturbances. A 2-hour exposure to a1000-ppm concentration affected the visualperception. Higher concentrations can pro duce narcotic effects. Heavy exposures may...