Published in the series MAK Value Documentations , Vol. 24 (2007) The article contains sections titled: Effects in Humans Effects on the CNS Renal toxicity Renal carcinogenicity Glutathione conjugation of trichloroethylene in test persons and in vitro Genotoxicity Animal Experiments and in vitro ...
None of these effects are seen in rats due to metabolic and pharmacokinetic differences nor can they be replicated in human tissues. The low incidences of rat kidney tumours seen in some cancer bioassays appear to be linked to high dose toxicity. Human epidemiology studies based on large well ...
Evaluation of the psychophysiological functions in humans exposed to trichloroethylene. To provide data on the psychophysiological efficiency of human beings exposed to solvent vapour currently used in the industry the effects of trichloroethylene (TCE) were evaluated by exposing six male university students...
effects, liver and lung damage, abnormal heartbeat, coma, and possibly death. In its ninth Report on Carcinogens, the National Toxicology Program determined that trichloroethylene is ‘reasonably anticipated to be a human carcinogen.’ The International Agency for Research on Cancer has determined ...
Administration of TCE in the diet of mice and rats at concentrations equivalent to doses of up to 300 mg/kg bw per day for two generations resulted in marginal effects on testicular weight and on survival of pups of both the F1 and F2 generations at the highest dose. In general, TCE ...
The toxic effects manifested in humansfrom inhaling trichloroethylene vapors areheadache, dizziness, drowsiness, fatigue, andvisual disturbances. A 2-hour exposure to a1000-ppm concentration affected the visualperception. Higher concentrations can pro duce narcotic effects. Heavy exposures maycause death due...
The International Agency for Cancer Research has established that TCE is likely to be carcinogenic in humans.
Despite these associations, the toxicological mechanism underlying trichloroethylene adverse effects on pregnancy remains largely unknown. The trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine (DCVC) induces mitochondrial-mediated apoptosis in a trophoblast cell line. To gain further understanding...
Based on a large number of in vitro studies and in vivo studies using proximal tubular cells from various mammalian species, it is generally accepted that 1,2-DCVC plays an important role in the nephrotoxic effects of TCE in humans (Cichocki et al. 2016). More recently, it has...
Effects of phenol feeding pattern on microbial community structure and cometabolism of trichloroethylene. Cometabolism of trichloroethylene (TCE) by phenol-fed enrichments was evaluated in four reactors with distinct phenol feeding patterns. The reactors were i... C.-C. Shih,ME Davey,J Zhou,......