It has been established that dendrimers conjugated or complexed with the carbohydrate triantennary N-Acetylgalactosamine (triantennary-尾-GalNAc) selectively accumulate within hepatocyte cells and selectively deliver therapeutic, prophylactic or diagnostic agents to the liver. Compositions of dendrimers ...
Novel triantennary N-acetylgalactosamine derivatives of tris(hydroxymethyl)aminomethane were synthesized and used to form complexes with the asialoglicoprotein receptor expressed on the hepatocellular surface. The equilibrium dissociation constants (K-D) of the complexes of the asialoglicoprotein receptor ...