Instead of the requirement that the treatments being compared exist in exact balance (circumstances in which the researcher would have no preference), clinical equipoise is based on an honest disagreement amongst knowledgeable professionals; as long as a genuine dispute exists concerning the superior...
40 Simulation has been widely implemented in the pharmaceutical sector to assist with the design of trials, often seeking to balance the cost of collecting data with the information (such as safety and/or efficacy) on the drug under consideration that these data will provide41. Clinical trial ...
This study tested the efficacy of a toothpaste containing enzymes and proteins reflecting those naturally occurring in saliva which play an important role in maintaining bacterial balance to improve gingival health condition and reduce supra-gingival plaque formation over a period of 13 weeks as compared...
Therefore, we were able to balance the control and treatment arms by village and roof type covariates. Allocation concealment was ensured through only the site lead in Nouna having encrypted/password-protected access to the household data and the subsequent use of an automated computer-generated ...
This approach was taken as a means of striking a balance between the dangers of committing type II errors vs overinterpreting significant findings that occurred simply by chance (type I errors). Readers are encouraged to exercise caution when interpreting 1-tailed findings and may choose to double...
A new pan-TB treatment regimen, consisting of novel agents to which no drug resistance exists, is a goal of the World Health Organization, with drugs that strike a balance between antimycobacterial activity, safety and duration of treatment17. Ganfeborole offers the possibility of a low-dose QD...
Subject randomization is intended to balance the proportion of vaccine refusing/vaccine endorsing participants. Parental vaccine hesitancy will not be assessed prior to enrollment. Such assessment may bias enrollment toward those individuals with greater vaccine acceptance through social desirability bias. ...
14 The SPPB is a performance-based test that includes 3 components: walking velocity, time for 5 repeated chair stands, and a balance test.12 A 0- to 4-point score is assigned to each test (4 = best), and scores are summed to yield an overall score ranging from 0 to 12 (12...
Thus, although alternative specifications are possible (eg, via multivariate distributions), we believe that the proposed specification provides a good balance between model complexity and flexibility. When the models in Equation 3 are fitted using MI, the joint distributions are approximated by first ...
Essai randomisé de trois stratégies de conseils de modifications du mode de vie chez des patients hypercholestérolémiques traités par ezetimibe en association à une statine (TWICE) Author links open overlay panelPhilippe Gabriel Steg a, Jean-Claude Verdier b, François Carré c, Bernadette ...