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For building the final model, we used the kuenm_mod function of the KUENM package [44] and as the settings, we chose to run 10 iterations of the 10-fold cross-validation with extrapolation and clamping as the type of projections [55]. The average output of replicates was used to ...
Functional data represent fold changes in receptor activity by gene variant. For example, a value of −4.1 is a 4.1-fold decrease in the respective measure of variant receptor activity compared to WT (i.e., no mutation). A value of 1.0 means no change from WT whereas n.d. indicates ...