2022年4月1日,中科院上海药物研究所徐华强/徐有伟团队在Cell Research上发表了题为 “Structural insights into ligand binding and activation ofthe human thyrotropin releasing hormone receptor” 的研究成果,该成果 首次报道了促甲状腺激素释放激素受体(thyrotropin-releasing hormone receptor, TRHR)结合内源TRH,以及Gq...
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Several new evidences have been reported including primary structure of TRHRs, distribution of TRHR mRNA, three dimensional structure of the TRH binding pocket, structure of the TRHR gene promoter, G-proteins and TRHR etc. Furthermore, a patient with central hypothyroidism caused by compound ...
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Peripheral tissue expression profile of porcine TRH mRNA was also investigated in this study. Co-expression of TRH and its receptor TRHR in the same tissue, especially in fat tissue, indicated the possibility of the existence of local paracrine/autocrine regulations of TRH on respective peripheral ...