Here we review the post-translational modifications of TRF1 and TRF2 and discuss the mechanisms by which these modifications contribute to the function of these two proteins.doi:10.1016/j.mad.2012.05.002John R. WalkerXu-Dong ZhuElsevier Ireland LtdMechanisms of Ageing & Development...
EPAS1 prevents telomeric damage-induced senescence by enhancing transcription of TRF1,TRF2,and RAD50 Telomeres are nucleoprotein structures located at the end of each chromosome,which function in terminal protection and genomic stability.Telomeric damage i... KQ Li,GJ Liu,XY Liu,... - 动物学研究...
Human telomeres are coated by the telomere repeat binding proteins TRF1 and TRF2, which are believed to function independently to regulate telomere length and protect chromosome ends, respectively. Here, we show that TRF1 and TRF2 are linked via TIN2, a previously identified TRF1-interacting pro...
TRF2 binds branched DNA to safeguard telomere integrity. Nat. Struct. Mol. Biol. 24, 734–742 (2017). Article CAS PubMed Google Scholar Santos-Pereira, J. M. & Aguilera, A. R loops: new modulators of genome dynamics and function. Nat. Rev. Genet. 16, 583–597 (2015). Article ...
Figure 2. Trf1 Deletion in Ink4Arf-Deficient, p53-Deficient, and Wild-Type Backgrounds Does Not Alter Mice Viability (A) Survival curve analysis of Trf1+/+ and Trf1lox/lox mice in Ink4Arf-deficient, p53-deficient, and wild-type backgrounds. (B) Representative images of mice of the in...
Moreover, knockdown of PinX1 caused delayed mitotic entry and reduced the accumulation of TRF1 on telomeres during this stage of the cell cycle. Taking these findings together, we suggest that one function of PinX1 is to stabilize TRF1 during mitosis, perhaps to promote transition into M ...
Although no clear telomere shortening or elongation was observed in short term cultured TRF1-deficient cells, abnormal telomere signals were observed, and TRF1-interacting telomere-binding factor, TIN2, lost telomeric association. Furthermore, another double-stranded telomeric DNA-binding factor, TRF2,...
Background: Human telomeres are coated by the telomere repeat binding proteins TRF1 and TRF2, which are believed to function independently to regulate telomere length and protect chromosome ends, respectively. Results: Here, we show that TRF1 and TRF2 are linked via TIN2, a previously ...
In several organisms, including mammals, telomeres are protected by a protein complex named shelterin that prevents DNA damage at the chromosome ends through the specific function of its subunits. Here, we reveal that the nuclear protein levels of shelterin components TRF1 and TRF2 decline in ...