【Trends in Pharmacological Sciences】基于计算和人工智能的药物代谢和转运预测方法 本文重点 1. 在过去十年中,包括机器学习(ML)在内的人工智能(AI)方法 和深度学习(DL)方法已经取得了令人瞩目的进展,并且已经被用于加速药物开发过程,并改进预测药物代谢、转运和 DDI。 2. 了解和预测复杂的药物代谢、转运和药物相互...
Trends in Plant Science Trends in Pharmacological Sciences (IF 13.503, CiteScore 20.1) 调节神经递质转运蛋白（NTTs）功能的化合物在临床上用于管控不同的神经精神疾病。尽管已发现这些化合物中大多数都可以选择性地与NTT的正构位点（orthosteric site）相互作用，但在不少NTT中也已发现有多种别构位点（alloster...
Trends in Plant Science Trends in Pharmacological Sciences (IF 13.503; CiteScore 20.1) 骨关节炎(OA)是一种最常见的关节炎,尽管它广泛发生,但目前尚无FDA认证的疾病治疗药物。最近的证据表明,多种分子通路的表观遗传失调是OA发病机理的基础,这提供了一种同时靶向的新的治疗方法。在本期中,Grandi和Bhutani...
The use of the Apple microcomputer for pharmacological bioassay studies Olav Thulesius Pages 218-219 select article The problem of recoveries in peptide release experiments Short communicationNo access The problem of recoveries in peptide release experiments Dieter K. Meyer, T. Feuerstein Page 220 selec...
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Trends in Pharmacological SciencesConigrave AD, Quinn SJ, Brown EM (2000) Cooperative multi-modal sensing and therapeutic implications of the extracellular Ca... AD Conigrave,SJ Quinn,EM Brown - 《Trends in Pharmacological Sciences》 被引量: 533发表: 2000年 Microcarriers in the engineering of car...
Natividad JMM, Verdu EF. Modulation of intestinal barrier by intestinal microbiota: pathological and therapeutic implications. Pharmacological Research. 69: 42-51 (2013). Article Neef A, Sanz Y. Future for probiotic science in functional food and dietary supplement development. Current Opinion in Clini...
Patients in the intervention group wer... GM Peterson,S Mclean,KS Millingen - 《Epilepsia》 被引量: 238发表: 1984年 Levetiracetam therapy in patients with brain tumour and epilepsy We studied the safety and efficacy of levetiracetam (LEV), a new AED with a different pharmacological profile ...
Pharmacological inhibition of bacterial β-glucuronidase prevents irinotecan-induced diarrhea without impairing its antitumor efficacy in vivo. Pharmacol Res. 2019;139:41–9. https://doi.org/10.1016/j.phrs.2018.10.029. Article PubMed CAS Google Scholar Wallace BD, Roberts AB, Pollet RM, Ingle ...
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