Intention tremor is a coarse hand tremor that is aggravated by goal-directed movement and is often caused by cerebellar lesions (e.g., due to strokes , trauma, multiple sclerosis ). Various medications and toxins are associated with tremor, most commonly ...
Clonazepam has been reported to be useful in ET with intention tremor [102] but another small study could not reproduce this [102]. Clozapine has been reported to be effective if a test dose (6.25 mg) shows a positive effect [103]. Clozapine is administered at night for its sleep-inducing...
While the science behind this mutation, as a paradigm for RNA-mediated nucleotide triplet repeat expansion diseases, has progressed rapidly, no treatment has proven effective at delaying the onset or decreasing morbidity, especially at later stages of the disease. Here, we demonstrated the beneficial...
In two experimental studies, cooling of the arms markedly reduced intention tremor severity in patients with MS [77, 35]. The authors argue that this effect might have been partly due to decreased muscle spindle function and decreased nerve conduction velocity, which in turn resulted in decreased...
Among FMR1 premutation carriers, about 40% of males over age 50 will ultimately develop FXTAS, manifesting with clinical features of progressive intention tremor and/or ataxia with gradual behavioral deficits and cognitive decline (Hagerman et al., 2001; Jacquemont et al., 2003; Willemsen et al...
Our ERP results support the view that treatment with the uncompe- titive NMDA receptor antagonist memantine improves glutamatergic signaling (Lipton, 2006) in FXTAS patients. This uncompetitive antagonist can block excessive activa- tion of the NMDA receptors while leaving normal physiological activity ...
Action tremors are known as intention tremor if they occur during a directed movement toward a target, as when a patient is asked to touch a finger to his or her nose during a medical examination. If the patient’s tremor begins during goal-oriented tasks requiring a high skill level (e....
dexterity, whereas reductions in force tremor amplitude following the RT program were restricted to the most affected limb of the ET group.These findings suggest that generalized upper limb RT program has the potential to improve aspects of manual dexterity and reduce force tremor in older ET ...
YugeKotaroHaraMunetsuguOkabeRumikoNakamuraYukiOkamuraHisayoshiingentaconnectOptics CommunicationsY u g e K , Hara M , Okabe R. Ghrel in improves dystonia andTremor in patients with Rett syndrome: a pilot study [J]. JNeurol Sci,2017,377(6) :219-223....
Another solution to cope with diseases that have tremor symptoms is surgical intervention. Thalamic lesioning was the first described surgical solution for ET. Deep brain stimulation (DBS) was performed in the 1990s by surgeons to treat ET and PD. During DBS surgery, electrodes are precisely implan...