Fig. 1.TREM2 domain, structure, ligands, signaling and function. (A) Schematic of TREM2 domain. SP = signaling peptide, Tm = transmembrane. Numbers indicate domain boundaries.(B)Schematic showing TREM2 structure, ligands and signaling. Ligands binding to TREM2 induce the interactions of TREM2...
此外,TREM2可以被解离素、解整合素金属蛋白酶10(ADAM10)以及γ-分泌酶从细胞表面切割,从而释放可溶性TREM2(sTREM2)。 Fig 2. TREM2 Protein Structure and Signaling Pathways TREM2在大脑、骨骼和毛囊干细胞等特定位置表达,对于组织的发育和功能维持具有重要作用。在细胞水平上,TREM2通过参与多种生物学过程(如吞噬...
此外,TREM2可以被解离素、解整合素金属蛋白酶10(ADAM10)以及γ-分泌酶从细胞表面切割,从而释放可溶性TREM2(sTREM2)。 Fig 2. TREM2 Protein Structure and Signaling Pathways TREM2在大脑、骨骼和毛囊干细胞等特定位置表达,对于组织的发育和功能维持具有重要作用。在细胞水平上,TREM2通过参与多种生物学过程(如吞噬...
此外,TREM2可以被解离素、解整合素金属蛋白酶10(ADAM10)以及γ-分泌酶从细胞表面切割,从而释放可溶性TREM2(sTREM2)。 Fig 2. TREM2 Protein Structure and Signaling Pathways TREM2在大脑、骨骼和毛囊干细胞等特定位置表达,对于组织的发育和功能维持具有重要作用。在细胞水平上,TREM2通过参与多种生物学过程(如吞噬...
Fig 2. TREM2 Protein Structure and Signaling Pathways TREM2在大脑、骨骼和毛囊干细胞等特定位置表达,对于组织的发育和功能维持具有重要作用。在细胞水平上,TREM2通过参与多种生物学过程(如吞噬作用、代谢过程、细胞存活和抗炎反应等),在不同背景下诱导细胞表型和功能变化。在病理学中,TREM2参与了包括阿尔茨海默病...
1) TREM2 structure and expression TREM2 belongs to a family of receptors referred to as the triggering receptors expressed on myeloid cells (TREM). Members of the TREM family are cell surface transmembrane glycoproteins with V-immunoglobulin extra-cellular domains and cytoplasmic tails [30]. The ...
We develop a model based on the TREM2 structure to explain how different TREM2 ligands might interact with the receptor and how disease risk variants may alter ligand interactions. Finally, we propose future experimental directions to establish the role and importance of these different interactions ...
The triggering receptor expressed on myeloid cells 2 (TREM2) gene is a recently identified susceptibility gene for AD. Here, our previous findings and the recent high-quality studies are comprehensively reviewed regarding the association of TREM2 variants with AD risk, the structure, ligand and ...
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pECMV-3×FLAG-TREM2 structure CAS No. Chemical Name: pECMV-3×FLAG-TREM2 Synonyms CBNumber: CB213288073 Molecular Formula: Molecular Weight: 0 MDL Number: MOL File: Mol file Request For Quotation Suppliers1 pECMV-3×FLAG-TREM2 Preparation Products And Raw materials ...