尽管TREM2参与早期发育阶段小胶质细胞介导的突触修剪已被报道,但TREM2在AD背景下是否以及如何调节小胶质细胞介导的突触消除仍不清楚。 2023年7月12日,厦门大学陈小芬和钟力领衔的研究团队在Immunity(IF:32.4)上在线发表题为TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q...
【参考文献】 Zhong et al., TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration, Immunity (2023), https://doi.org/10.1016/j.immuni.2023.06.016 文章中图片均来自于参考文献
2023年7月12日,厦门大学陈小芬和钟力领衔的研究团队在Immunity(IF:32.4)上在线发表题为TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration的研究论文。该研究发现,小胶质细胞中的TREM2受体可以通过结合补体蛋白C1q进而抑制AD大脑中的补体激活和补体介导...
Although post-ischemic inflammation induced by the innate immune response is considered an essential step in the progression of cerebral ischemia injury, the role of triggering receptor expressed on myeloid cells 2 (TREM2) in the pathogenesis of ischemic stroke remains to be elucidated. Here, we ...
of TREM2 protects against cerebral ischemia/reperfusion injury W Rong,L Xiangpen,X Pengfei,... 被引量: 6发表: 2017年 Pharmacological inhibition of the triggering receptor expressed on myeloid cells-1 limits reperfusion injury in a porcine model of myocardial infarction. Aims Limitation of ischemia...
Furthermore, deletion of the Tyrobp-associated receptorTrem2significantly aggravated mouse AD development, whereas Trem2 agonist treatment conferred protection against AD.#Our findings suggest a novel role for the Trem2/Tyrobp axis in AD development in mice. Enhancement of Trem2/Tyrobp signaling may ...
Variants in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) were recently found to increase the risk for developing Alzheimer's disease (AD). In the brain, TREM2 is predominately expressed on microglia, and its association with AD adds to increasing evidence impli...
Triggering receptor expressed on myeloid cells 2 (TREM2) signaling is considered to regulate anti-inflammatory responses in macrophages, dendritic cell maturation, osteoclast development, induction of obesity, and Alzheimer’s disease pathogenesis. Howev
DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TR... TREM2 in Alzheimer’s disease The Emerging Roles and Therapeutic Potential of Soluble TREM2 in Alzheimer’s Disease Non-pathological roles of microglial TREM2/DAP12: TREM2/DAP12 regulates the ...
DAP12 stabilizes the C-terminal fragment of the triggering receptor expressed on myeloid cells-2 (TREM2) and protects against LPS-induced pro-inflammatory response. J. Biol. Chem. 290, 15866–15877 (2015). Article CAS PubMed PubMed Central Google Scholar Jay, T. R. et al. TREM2 ...