TPM1 knockdown ameliorated LPS-induced inflammation in WT retinas yet exaggerated the inflammation in TREM2 Conclusions:We demonstrate that TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway. Our findings suggest that TPM1 could be a potential target for therapeutic ...
Here, we elucidated the molecular mechanism by which TREM2 promotes the transcription of CD36 by upregulating C/EBPα via the PI3K/AKT/CREB pathway in microglia. TREM2-induced upregulation of CD36 subsequently enhanced the phagocytosis of Aβ and protected neuronal cells against Aβ-induced cellu...
AVE 0991 attenuates oxidative stress and neuronal apoptosis via Mas/PKA/CREB/UCP-2 pathway after subarachnoid hemorrhage in rats. Redox Biol. 2018;20:75–86. Article PubMed PubMed Central CAS Google Scholar Xu N, Zhang Y, Doycheva DM, Ding Y, Zhang Y, Tang J, Guo H, Zhang JH. ...
TORC2蛋白抗原,CREB转录共激活因子TORC2蛋白抗原Torsin A蛋白抗原,扭转蛋白A蛋白抗原Torsin B蛋白抗原,扭转蛋白B蛋白抗原TP-5/Thymopentin蛋白抗原,*蛋白抗原TP53I11蛋白抗原,肿瘤蛋白P53诱导蛋白11蛋白抗原TP53I13蛋白抗原,肿瘤蛋白p53诱导蛋白13(肿瘤抑制基因)TP53I8蛋白抗原,肿瘤蛋白p53诱导蛋白8TP53TG3蛋白抗原,p53...
白藜芦醇通过调节BDNF/Akt/CREB及TREM1/2表达失衡抑制脂多糖诱导的BV2小胶质细胞炎症反应1 (10-6-10-10 mol·L-1)减少LPS诱导的BV2细胞培养上清中的LDH释放,并下调IL-1β,IL-6及TNF-α的mRNA表达,逆转BDNF/Akt/CREB及TREM1/2的蛋白表达失衡... 徐静娴,刘森,高欣冉,... - 《中国药理学通报》 被引量...
干预结束后,用水迷宫实验检测小鼠空间学习记忆能力,Nissl染色检测小鼠海马组织神经元损伤,Westernblot检测小鼠海马组织中PSD93,PSD95,BDNF,CREB,IL-6,IL-1β,TNF-α,Iba-1,i NOS,CD206,Arg1,TREM2,NF-κB,p-STAT3,STAT3蛋白表达水平,q RT-PCR检测海马组织炎症因子及髓系细胞触发受体2 (triggering receptor ...
The treatment of a pure neuronal hippocampal culture with soluble CX3CL1 activated the transcription factor CREB and ERK1/2, but no JNK or p38 MAPK [129], and also induced the translocation of NF-κB p65 subunit to the nuclIentu. Js. M. oNl. SFc-i.κ20B18p, 169,5x FsOuRbPuEnER...