于是,他们研究了TREK-1基因敲除小鼠和野生型小鼠心脏裂解物中MAPK的变化。他们发现,与野生型小鼠相比,TREK-1基因敲除小鼠的JNK激酶磷酸化出现差异(图3)。 由于TREK-1对机械牵张敏感,故研究人员决定测试一下,暴露在机械牵张下的TREK-1基因敲除小鼠的JNK磷酸化是否受到影响。结果表明,机械牵张导致野生型小鼠的JNK磷酸...
两项试验还评估了其他次要终点，包括肺部恶化率和囊性纤维化问卷修订版呼吸领域(CFQ-RRD)评分相对于起始的变化。在试验1和试验2中，与Trikafta相比，ALYFTREK治疗导致从起始到第24周ppFEV1的绝对变化的LS平均差异分别为0.2个百分点（95%CI：-0.7,1.1）和0.2个百分点（95%CI：-0.5,0.9）。由于试验1和试...
每日服用一次的囊性纤维化三联组合疗法Alyftrek获得FDA批准 据Vertex Pharmaceuticals(福泰制药)于2024年12月20日宣布,美国食品药品监督管理局(FDA)批准Alyftrek(vanzacaftor/tezacaftor/deutivacaftor)用于治疗6岁及以上在CFTR基因中至少有一种(F508...
参考来源:‘Vertex Announces US FDA Approval of ALYFTREK™, a Once-Daily Next-in-Class CFTR Modulator for the Treatment of Cystic Fibrosis’、‘Vertex Announces U.S. FDA Approval for TRIKAFTA (elexacaftor/tezacaftor/ivacaftor and ivacaftor) to Include Additional Non-F508del TRIKAFTA-Responsive V...
Nebulizer Use and Maintenance by Cystic Fibrosis Patients: A Survey Study. Respiratory Care 2004; 49(12): 1504-1508. 1When used with a PARI LC reusable nebulizer2Tiffin, et al. Efficacy and Variability of Aerosol Delivery from Portable DC-Powered Compressor/Nebulizer Systems Canadian Journal of ...
参考来源:‘Vertex Announces US FDA Approval of ALYFTREK™, a Once-Daily Next-in-Class CFTR Modulator for the Treatment of Cystic Fibrosis’、‘Vertex Announces U.S. FDA Approval for TRIKAFTA (elexacaftor/tezacaftor/ivacaftor and ivacaftor) to Include Additional Non-F508del TRIKAFTA-Responsive ...
Alyftrek is used to treat cystic fibrosis (CF) in people aged 6 years and older with at least one F508del mutation or another responsive mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Includes Alyftrek side effects, inte
参考来源:‘Vertex Announces US FDA Approval of ALYFTREK™, a Once-Daily Next-in-Class CFTR Modulator for the Treatment of Cystic Fibrosis’、‘Vertex Announces U.S. FDA Approval for TRIKAFTA (elexacaftor/tezacaftor/ivacaftor and ivacaftor) to Include Additional Non-F508del TRIKAFTA-Responsive ...
参考来源:‘VertexAnnounces US FDA Approval of ALYFTREK™, a Once-Daily Next-in-Class CFTR Modulator for the Treatment of Cystic Fibrosis’、‘Vertex Announces U.S. FDA Approval for TRIKAFTA (elexacaftor/tezacaftor/ivacaftor and ivacaftor) to Include Additional Non-F508del TRIKAFTA-Responsive Var...
Putney Bridge - Tower Bridge 25 km & 16 Bridges Food & Drink Walk Only Join 2500 walkers and trek across the Capital taking in unrivalled views of the skyline, and historic landmarks. Setting out from Putney Bridge start we head East towards the City, zig-zagging over 16 historic bridges...