研究团队追踪了TCR转基因细胞(TCR-transgenic cells)在肠道中的自然历史,以此作为Treg cells获取和维持免疫调节功能的一个模型。通过在解剖微小环境中检查这些细胞,研究揭示了关键相互作用对于增强效应性调节性T细胞(eTreg cells)的抗原刺激和效应功能至关...
The transcription factor TCF-1 is essential for the development and function of regulatory T (Treg) cells; however, its function is poorly understood. Here, we show that TCF-1 primarily suppresses transcription of genes that are co-bound by Foxp3. Single-cell RNA-sequencing analysis identified ...
MDSCs和Tregs 产生的因子形成正反馈环,促进增殖,增强抑制环境。 图片来源:Regulatory T cells :mechanisms of differentiation and function 三、Treg细胞的应用 已知Treg细胞数量过低或功能减弱会引起免疫系统反应过激,从而可能导致自身免疫性疾病的发生;而数量过高或异常激活会抑制免疫反应,则可能会引起肿瘤的发生。因此,...
[5] Schiering C, Krausgruber T, Chomka A, et al. The alarmin IL-33 promotes regulatory T-cell function in the intestine. Nature. 2014;513(7519):564-568. [6] Ohnmacht C, Park J-H, Cording S, et al. The microbiota regulates...
近日,来自英国牛津大学的Fiona Powrie和Emily E. Thornton合作在Nature上发表了研究论文Immune microniches shape intestinal Tregfunction。在本研究中,作者利用体内活体成像、光激活引导的单细胞RNA 测序和空间转录组学,在耐受和炎症环境中,通过空间和时间跟踪对Hh有反应性的 T 细胞的生理过程,揭示了黏膜固有层是支持效...
2.https://www.genengnews.com/news/crispr-screen-reveals-control-knob-for-regulatory-t-cells/ 3.https://www.cell.com/immunity/pdf/S1074-7613(20)30266-1.pdf 4.https://www.fiercebiotech.com/research/fine-tuning-regulatory-t-cells-to-treat-cancer-autoimmune-diseases 5.https://www.eurekalert...
图片来源:Regulatory T cells :mechanisms of differentiation and function 三、Treg细胞的应用 已知Treg细胞数量过低或功能减弱会引起免疫系统反应过激,从而可能导致自身免疫性疾病的发生;而数量过高或异常激活会抑制免疫反应,则可能会引起肿瘤的发生。因此,Treg细胞可谓是体内免疫系统的一把“双刃剑”,可在肿瘤免疫、自身...
4.Qi Jiang, Guocan Yang, Qi Liu, Shengjun Wang, Dawei Cui .Function and Role of Regulatory T Cells in Rheumatoid Arthritis. Front Immunol. 2021; 12: 626193.
However, regulatory T cells (Tregs) also rely on CD25 for their proliferation, survival, and regulatory function. Therefore, CD25-blockade may compromise Treg protective role against rejection. We analysed in vitro the effect of basiliximab (BXM) on the viability, phenotype, proliferation and ...
Treg细胞就是调节性T细胞(regulatory T cells),是免疫系统中的基本细胞,是Sakaguchi等人[1]于1995发现的,以表达Foxp3、CD25、CD4为细胞表型特征。它是Th1、Th2、Th17之外的T细胞亚群,属于一类增殖能力较低的CD4+ T细胞亚群,具有免疫抑制作用,能够分泌IL-4、IL-10和TGF-β等细胞因子,在免疫稳态和诱导免疫耐受中发...