Lupus nephritis (LN) is a frequent and serious complication of systemic lupus erythematosus (SLE), impairing patients' quality of life and significantly increasing mortality. Despite optimizing the use of conventional immunosuppressants and other biological drugs, its management remains unsatisfactory. This...
[Results]The therapeutic effect and adverse events in the two groups were significantly different,with statistical significance.[Conclusion]TL combined with hormone comprehensive treatment for lupus nephritis has the ideal efficacy and safety.Compared with CsA and it can reduce the albuminuria and control...
Lupus nephritis is a serious problem. Its symptoms, though, are not always dramatic. For many, the first noticeable symptom is swelling of the legs,anklesand feet. Less often, there can be swelling in the face or hands. Other symptoms can vary from person to person and from day to day....
P. et al. Remission of proliferative lupus nephritis following B cell depletion therapy is preceded by down-regulation of the T cell costimulatory molecule CD40 ligand: an open-label trial. Arthritis Rheum. 52, 501–513 (2005). Article CAS PubMed Google Scholar van Vollenhoven, R. F. et...
Kidney damage: A type of kidney inflammation called nephritis can delveop when the kidneys cannot properly filter toxins and waste from the blood. Metabolic and thyroid disorders:Lupus increases the risk for autoimmune thyroid disease. Connective tissue and nerve damage: Lupus can cause damage to th...
MRL/lpr mice suffer from a systemic lupus erythematosus-like autoimmune disease. We studied the effects of oral treatments with Ninjin-youei-to (NYT, Ren-shen-yang-rong-tang, 1000 mg/kg/day), a suboptimal dose (2 mg/kg/day) of prednisolone(PSL) and their combination on nephritis in MRL...
et al. A multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of treatment with sirukumab (CNTO 136) in patients with active lupus nephritis. Arthritis Rheumatol. 68, 2174–2183 (2016). Article CAS PubMed PubMed Central Google Scholar Wallace, D...
An ongoing trial is testing the efficacy of ravulizumab, a humanized monoclonal antibody that inhibits complement protein C5 and is indicated for the treatment of atypical haemolytic uraemic syndrome in patients affected by lupus nephritis and IgAN (NCT04564339). 3.3. Rituximab The involvement of ...
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Patients with lupus nephritis and anti-neutrophil cytoplasmic autoantibody vasculitis were not included because of the substantial literature that already exists regarding cardiovascular risk in these populations. Histologic features and clinical data provided at the time of biopsy were used to exclude ...