Direct acting antiviral (DAA) treatment regimens for patients with HIV〩CV coinfection are similar to those for mono﹊nfected patients, but HIV stage, ART and CD4 count can also influence the choice of regimen. Assessment for potential drugヾrug interactions between ART and DAA therapy is of ...
A method for the treatment of hepatitis C infection genotype 1, 2, 4, 5, or 6, but not genotype 3 is provided comprising administering an effective amount of a combination of Compound (I), Compound (II), and Compound (III), or independently optionally their pharmaceutically acceptable salt,...
Patients remain on this regimen for 6 to 12 months in order to achieve a sustained viral response, defined as having an undetectable viral load for at least 6 months posttreatment.10 In addition to physiological side effects, there are also significant neuropsychiatric side effects, including ...
Chronic infection with hepatitis C virus (HCV) carries a significant global health burden in both children and adults, with approximately 3% of the world's population infected. The prevalence of HCV in children is estimated to be 0.4% in the United Kingdom (UK), with a greater than ten-fol...
Which DAA regimen to use depends on several factors, including liver disease severity, other health conditions, previous treatment attempts and hepatitis C virus (HCV) genotype. Some medications work only against specific genotypes, but the newest ones work against all of them. ...
This multicenter, randomized, controlled, double-blind, phase III study in 704 patients with chronic hepatitis C infection compared treatment with consensus interferon (CIFN), a non-natural recombinant type-1 interferon, with a standard regimen of recombinant interferon alfa-2b (IFN-alpha2b). ...
Used in combination withribavirin(RBV), sofosbuvir (Sovaldi, Gilead Sciences, Inc) would allow for the first all-oral interferon-freeHCVtreatment regimen and is thereby expected to improve compliance and reduce toxicity compared with current therapies. ...
A system for administering a treatment to individuals infected with a virus such as hepatitis. The system includes an enclosure and at least one gas supply that is used to create an altered atmospheric environment within the enclosure. The patients walk into the enclosure, the super-atmospheric en...
Antiviral treatment of chronic hepatitis B and C is aimed at controlling symptoms and abnormal biochemistry and particularly the progression to cirrhosis and liver cancer. Interferon-[alpha] is usually employed but there is no consensus concerning the best regimen. Patients who have developed cirrhosis...
In a single-arm, multicenter study of treatment-naïve adults with HCV GT1 infection without cirrhosis and with CKD G4 or G5, 20 patients were treated with this regimen for 12 weeks. Patients with HCV GT1a infection also received RBV (n = 13), whereas those with GT1b infection did ...