Treatment refractory depressionStagingAntidepressive agentsPredictionSystematic reviewTreatment resistant depressant (TRD) is classified in different staging models, but these are not used routinely. We aimed to identify staging models for TRD and compare them regarding predictive utility and reliability. ...
Refractory, treatment-resistant depression may occur in the palliative care setting. Comprehensive end-of-life care is best provided by an interdisciplinary team that includes physicians, nurses, mental health clinicians, and spiritual counselors because these patients and their families have a...
How well is your depression treatment working? Does it help a bit, but you still feel as if the darkness has not lifted? Perhaps you feel the treatment isn't working at all. If so, you could have treatment-resistant depression (TRD), also called refractory depression. ...
TREATMENT-REFRACTORY DEPRESSIONSEROTONIN REUPTAKE INHIBITORSEXTENDED-RELEASE QUETIAPINEPatients with treatment-resistant depression (TRD) are those with major depressive disorder that has not responded adequately to treatment. The causes of depression are not fully understood, although there is evidence to ...
Patients were required to have moderate to severe depression as defined by a Montgomery Asberg Depression Rating Scale (MADRS) score of >19, and have TRD at Stage II of the Thase and Rush classification [1]. This requires failure to respond to adequate courses of two different antidepressants....
New antidepressants Refractory depression Neurokinins/Substance P Antidepressants: how fast? Antidepressants and the brain Early-onset antidepressant strategies Active placebos v antidepressants for depression Somatic symptoms in treatment-resistant depression...
This chapter discusses whether patients with treatment-refractory depression (TRD) have the same right as patients with other refractory illnesses to control when to terminate active treatment of their psychiatric disorders. The chapter questions the rat
Consequently, prolonged trials extend- ing beyond 10 weeks, particularly in refractory cases, have been proposed to potentially elicit therapeutic responses [28, 29]. Moreover, among elderly individuals who suffer from depression, a timeframe exceeding 12 weeks might be essen- tial for ...
With deeper understanding of the neurobiological pathophysiology of depression, have come deeper insights into the potential targets for neuromodulation. The most rigorously investigated of these techniques has been vagal nerve stimulation (VNS), which was first reported as a treatment for refractory epilep...
The gold-standard non-pharmacological treatment for depression is electroconvulsive therapy (ECT), which has been shown to have a significant and relatively immediate effect on depressive symptoms and suicidal ideation via a generalized seizure, albeit in a minority of TRD patients [19, 20]. However...