Inherited retinopathies are devastating diseases that in most cases lack treatment options. Disease-modifying therapies that mitigate pathophysiology regardless of the underlying genetic lesion are desirable due to the diversity of mutations found in such diseases. We tested a systems pharmacology-based st...
Immediately after completing and recording the alcohol intakes on the third 24-hour deprivation-re-access cycle, animals were anaesthetized by intramuscular administration of ketamine (90 mg/kg)/xylazine (10 mg/kg) to obtain blood samples by cardiac puncture and perfused intracardially with 100 ml...
the final dialysate was lyophilized and characterized for particle size and drug loading. treatments mice were randomly assigned into 4 groups of 10 animals each. mice were first anesthetized with a mixture of ketamine hydrochloride and xylazine hydrochloride and then received a single 30-渭l ...
Mice were anaesthetized with an intraperitoneal injection of 120 mg/kg ketamine (cp-pharma) and 20 mg/kg xylazine (cp-pharma) and placed on a heated table. Orotracheal intubation was performed using an 18 G metal cannula (Scireq, Canada), with a suture sealing the wall of the trach...
Uveal melanoma, a highly aggressive intraocular tumor and the second most common form of ocular malignancy, currently lacks effective therapeutic options. Therefore, this study addresses an unmet medical need by developing nanostructured lipid carriers (NLC) as a potential delivery system for melatonin ...
Gene therapy for the selective treatment of brain tumours is intriguing, particularly given the limited efficacy of currently available therapeutic options. In thirteen studies that performed clinical trials with gene therapy, results showed an increase in mean survival time ranging from 8.9 months to ...
Few effective therapeutic options are currently available for the treatment of non-small cell lung cancer (NSCLC) with brain metastases (BM). Recent evidence shows that NSCLC patients with BMs respond well to afatinib, but little is known about the underlying mechanisms. In this study, we evaluat...
For infection, two groups of index female hamsters of 6-8 weeks old were anesthetized with ketamine/xylazine/atropine and inoculated intranasally with 50 µL containing 1×104 TCID50 of either SARS-CoV-2 WT virus or the 3CLprores virus(day 0). In the morning of day 1 post-infection...
Gene therapy for the selective treatment of brain tumours is intriguing, particularly given the limited efficacy of currently available therapeutic options. In thirteen studies that performed clinical trials with gene therapy, results showed an increase in mean survival time ranging from 8.9 months to ...
Physiological studies may be conducted on animals with corneal electrocardiograms (ERGs) at 60 and 90 days. Prior to testing, the rats are to be adapted to the dark overnight and anesthetized under red light with ketamine and xylazine. See, for example, Peachy et al.,Vis Neurosci.2002 Novemb...