A recently introduced model solves these technical problems and provides a solid theoretical basis for the study of populations evolving in continuous space. We present a detailed algorithm to simulate...
Opinion statement Despite its history as one of the most impactful toxicities associated with cytotoxic cancer therapy, oral mucositis (OM) remains an unmet clinical need which affects hundreds of thousands of patients. Descriptions of its complex pathogenesis have provided mechanistic targets which are ...
I’m really excited about [this therapy] and oral SERDs, mostly because it’s adding treatment options for our hormone receptor–positive patients, and we need more hormone-based therapies. [These agents are] generally easier to tolerate, [patients don’t need] to come in and ge...
Doctors should be educated about treatment options for chronic pain, including non-pharmacologic therapies, as well as about patient risk assessment and proper prescribing, while patients should be educated about both the benefits of opioid analgesics and their potential risks, including death and side...
hair loss, mouth sores, stomach upset: rapidly dividing cells in hair roots and cells that line the digestive tract may also be affected. As a result, side effects may include loss of hair, poor appetite, nausea and vomiting, diarrhea, or mouth and lip sores (mucositis).In...
The restoration of barrier function by growth- factor administration has been highly successful in the treatment of inflammatory bowel disease161 and oral mucositis associated with cytotoxic therapy162. Concluding remarks Despite an enormous increase in our understanding of the immune mechanisms involved in...
Also, we look for lesions in the mouth: mucositis-like ulcers, sores. Weight loss is a very important sign when it comes to evaluating chronic GVHD. In 2014, the National Institutes of Health [NIH] standardized the way we do scoring for chronic GVHD.3 What we do now when we evaluate ...
[65]However, follow-up from both of these trials is relatively short, particularly with an expected median survival in excess of 60 months for interferon-treated patients. Toxicity of the combination of cytarabine and interferon-alpha has been substantial, with nausea, vomiting, mucositis, diarrhea...
and impaired release of toxic payloads into the cytoplasm. Combination therapies are more promising than single-agent therapies for overcoming drug resistance. FDA-approved ADCs provide valuable treatment options for difficult-to-treat patient populations, but drug resistance is a frequently encountered li...
mucositis, difficulties in speaking, painful swallowing, and predisposition to oral infections. In this review, we will explore the clinical insights of cancer treatment-related xerostomia, discuss its pathophysiology, evaluate the available treatment options and ongoing candidates, and provide future ...