Fluosol, a member of the family of compounds known as perfluorocarbons, solubilizes large volumes of oxygen which should be beneficial in vaso-occlusive crises. A clinical trial using Fluosol in the management of sickle cell crisis was undertaken in seven patients, three men and four women, ...
Sickle cell disease (SCD), which affects approximately 100,000 individuals in the USA and more than 3 million worldwide, is caused by mutations in the βb globin gene that result in sickle hemoglobin production. Sickle hemoglobin polymerization leads to
Sickle cell disease or sickle cell anemia is the most common of the hereditary blood disorders among black people of African descent worldwide. Learn about symptoms, treatment, causes, inheritance, testing, complications, and more.
Sometimes a red blood cell exchange is performed. This process removes some of the sickle blood cells and replaces them with normal (non-sickle) blood cells. It is done when the sickle cell crisis is so severe that other forms of treatment are not helping. Pain crises Pain crises in ...
Purified poloxamer 188 for treatment of acute vaso-occlusive crisis of sickle cell disease: a randomized controlled trial. JAMA 2001;286:2099-106.Orringer... EP Orringer,JF Casella,KI Ataga,... - 《Jama the Journal of the American Medical Association》 被引量: 357发表: 0年 Purified Poloxa...
Sequential nitric oxide measurements during the emergency department treatment of acute vasoocclusive sickle cell crisis Lopez BL, Davis-Moon L, Ballas SK, Ma XL. Sequential nitric oxide measurements during the emergency department treatment of acute vasoocclusive sickle cell... BL Lopez,L Davis-Moon...
A therapeutic plan that emphasized oral narcotic analgesia was instituted for the treatment of painful crisis of sickle cell anemia. Of the 100 adult sickle cell syndrome patients registered at North Central Bronx Hospital, 15 were identified as using the emergency department facilities three or more...
The case involves a 38‐year‐old female of Nigerian descent with sickle cell anemia (SCA, βS/βS genotype), no α‐globin gene deletion and no glucose 6‐phosphate dehydrogenase deficiency. Over the past two decades, the patient received routine care at the National Institutes of Health (...
The classic view of sickle cell disease pathophysiology involves polymerization of mutated hemoglobin (HbS) leading to red blood cell (RBC) sickling with subsequent hemolytic anemia, painful vaso-occlusive crisis (VOC) and acute chest syndrome (ACS). ...
Based on recent successes and the scientific enthusiasm in gene therapy, the FDA has approved on December 8th2023, Lyfgenia™ (lovotibeglogene autotemcel - lovo-cel), a lentiviral vector-based gene therapy (Bluebird Bio) for the treatment of patients with sickle cell disease (SCD) ages 12...