Figure Inflammatory, Immunologic, and Pathobiologic Features Leading to Severe Asthma. Type 2 inflammation is most commonly initiated by the adaptive immune system on recognition of allergens through the actions of thymic stromal lymp...
It's calledTezspire(tezepelumab-ekko). The FDA approved it as an add-on maintenance treatment for severe asthma in patients ages 12 and older. Tezspire is a human monoclonal antibody. It is a first-in-class drug for the treatment of advanced asthma. It's administered via injection and ...
Severe asthma often requires high-dose corticosteroid therapy. However, steroid therapy is fraught with many side effects. There are conflicting reports in... MJ Coffey,G Sanders,WL Eschenbacher,... - 《Chest》 被引量: 94发表: 1994年 Controlled trial of methotrexate in patients with severe chr...
Emergency Department Treatment of Severe Asthma: Metered-Dose Inhaler Plus Holding Chamber Is Equivalent in Effectiveness to Nebulizer - ScienceDirect To compare the effectiveness of administration of albuterol by nebulizer or by a metered-dose inhaler having a holding chamber attachment (hereafter "in...
Omalizumab is a humanized monoclonal anti-IgE antibody recently approved for the treatment of severe allergic asthma. This drug inhibits allergic responses by binding to serum IgE, thus preventing their interactions with cellular IgE receptors. Omalizumab is also capable of downregulating the expression ...
EP.1:Overview of Asthma EP.2:Role of Type 2 Inflammation in Asthma EP.3:Signs of Severe Asthma and the Underlying Pathophysiology EP.4:Multidisciplinary Care for Patients With Asthma EP.5:Predicting Exacerbation of Asthma EP.6:Treatment Landscape of Asthma ...
Background:Dupilumab is a monoclonal anti-IL-4Rα antibody developed for the treatment of severe asthma (SA). An early access programme for dupilumab was opened in France in SA patients experiencing unacceptable steroids side-effects and/or life-threatening exacerbations. Objective:To assess changes...
The development of monoclonal antibody therapies targeting specific components of the pathways relevant to asthma pathophysiology has revolutionized treatment of severe asthma both in adults and children and helped to further unravel the heterogeneity of this disease. However, the availability of multiple ag...
ES3-2 Stratified or Personalised Approaches to the Treatment of Severe Asthma 来自 Semantic Scholar 喜欢 0 阅读量: 3 作者: S Holgate 年份: 2010 收藏 引用 批量引用 报错 分享 全部来源 求助全文 Semantic Scholar 0关于我们 百度学术集成海量学术资源,融合人工智能、深度学习、大数据分析等技术,为科研...
Asthma is one of the most common respiratory diseases worldwide - affecting almost 300 million people - and around 3 to 5% of these have severe asthma. This leads to daily symptoms of breathlessness, chest tightness and cough, along with repeated asthma attacks which require frequent hospitalisatio...