Developing an algorithm to standardize the management of GVHD in HCT recipients was one of the panel’s objectives because, just as there are many different ways to perform transplants, there “are many different ways to treat GVHD,” said Saad, who added that there may be as many as 10 ...
From the transplant physician's perspective, however, advances in the ability to identify well-matched donors, supportive care and promising conditioning regimens with low toxicity and transplant complications support the development of new HCT trials for sickle cell disease as the risk/benefit ratio ...
Despite advances that have improved survival after allogeneic hematopoietic stem cell transplantation (HCT), chronic graft-versus-host disease (GVHD) remains a leading cause of late morbidity and mortality after transplant. Current treatment options show limited efficacy in steroid-refractory disease, and...
The prevalence of CRC was comparatively low in the 1950 s, and the incidence of the disease increased later because of unmet screening methods and lifestyles. The mass formation of a tumor develops when healthy cells in the lining of the colon or rectum grow out of control. A tumor could ...
In a study by Batsche E et al [65], dCas9 tool was used to study the role of methylation DNA in the alternative splicing of HCT116 colon cancer cells. They also examined the influence of DNA methylation in MCF10A breast cancer model and ALL patients. dCas9 tool was used to target ...
Although HAART has made long-term suppression of HIV a reality, drug resistance, drug toxicity, drug penetration, adherence to therapy, low levels of continued viral replication in cellular reservoirs and augmentation of host immune responses are some of the most important challenges that remain to ...
Statins are one of the most frequently prescribed medications for decreasing plasma low-density lipoprotein cholesterol (LDL-C) worldwide. Since compactin was first isolated fromPenicillium citrinumin 1970s, a variety of statins such as pravastatin, atorvastatin, lovastatin and simvastatin (commonly presc...
www.nature.com/scientificreports OPEN Exploring the mechanism of andrographolide in the treatment of gastric cancer through network pharmacology and molecular docking Ravi Prakash Yadav 1, Susanta Sadhukhan 1, Makhan Lal Saha 2, Sudakshina Ghosh3 & Madhu...
The recipient is prepared for the transplant by potent immunosuppressive treatment, usually by chemotherapy and/or radiotherapy. This may then be followed by the transfer of autologous haematopoietic cells (auto-HCT; cells harvested from the recipient before patient conditioning (Fig. 1)) or allogeneic...
5FU-SLN4 was highly cytotoxic against HCT-116 cells and significantly inhibited subcutaneous tumor growth in mice compared with 5-FU. This emphasizes the significance of developing a smart nano-delivery system to optimize the delivery efficiency of anticancer drugs to tumors....