aThe optimal goal of my lab is to develop a radiation-free and GVHD-preventive approach of HCT. We recently reported that a monoclonal antibody, anti-CD3, was successfully used to replace the classical TBI in mouse HCT models, and the new anti-CD3 regimen prevented GVHD. Furthermore, we ob...
Treatment of patients (PTS) with chemotherapy-refractory chronic lymphocytic leukemia (CLL) with nonmyelo- ablative (NM) conditioning and hematopoietic cell transplantation (HCT) from HLA-matched related (MRD) or unrelated donors (URD) [abstract]. Biol Blood Marrow Transplant. 2004;10:26....
Developing an algorithm to standardize the management of GVHD in HCT recipients was one of the panel’s objectives because, just as there are many different ways to perform transplants, there “are many different ways to treat GVHD,” said Saad, who added that there may be as many as 10 ...
(Neu#), number of lymphocytes (Lym#), number of single-core cells (Mon#), number of eosinophils (Eos#), number of alkaline granulocytes (Bas#), red cell count (RBC), hemoglobin concentration (HGB), hematocrit (HCT), average red blood cell volume (MCV), average red blood cell ...
However, the CSC surface markers are seemingly inconsistently expressed on CSCs of the same cancer type, which hinders the selection process [36]. In the other method, CSCs are enriched in specific media, such as hanging drops, gyratory rotation and spinner flasks, and ultralow attachment plates...
Many of these patients have been on steroids before or have gone through a lot in their treatment. Adding on systemic therapies has risks, and they’re not trivial.For dry eye syndrome or a feeling of sand or irritation in the eyes, eye drops are the best way to focus therapy. We ...
Statins are one of the most frequently prescribed medications for decreasing plasma low-density lipoprotein cholesterol (LDL-C) worldwide. Since compactin was first isolated fromPenicillium citrinumin 1970s, a variety of statins such as pravastatin, atorvastatin, lovastatin and simvastatin (commonly presc...
In a study by Batsche E et al [65], dCas9 tool was used to study the role of methylation DNA in the alternative splicing of HCT116 colon cancer cells. They also examined the influence of DNA methylation in MCF10A breast cancer model and ALL patients. dCas9 tool was used to target ...
Bortezomib can be given alone given every other week, or as part of low-intensity VRd, to combine the beneficial effects of bortezomib and lenalidomide49. In patients unable to access or tolerate bortezomib, ixazomib is a reasonable alternative that has shown benefit in a placebo controlled ...
Before first HCT, he had been administered 1 course of azacytidine, but the response had been ineffi- cient. Next, he had received idarubicin and low-dose cytarabine. In the first HCT, the patient had received HLA-matched related donor peripheral blood. The patient had achieved neutrophil ...