Learn about TAGRISSO® (osimertinib), a targeted therapy for patients with certain types of EGFRm non-small cell lung cancer (NSCLC).
Diabetic foot infections (DFIs) are a significant complication in diabetes mellitus, leading to increased morbidity, hospitalizations, and healthcare burdens. The growing prevalence of antibiotic-resistant pathogens has reduced the efficacy of convention
Creatinine kinase (CK) was found to be 232.48 µkat/L (13 921 IU/L) (normal: 0.833-5.133 µkat/L; 50-308 IU/L). Electromyography and left vastus lateralis muscle biopsy showed findings of myonecrosis. Anti-HMGCR assay was strongly positive with antibodies > 200 chemiluminescent units...
Monitor patients closely for symptoms and signs that may be clinical manifestations of underlying immune-mediated adverse reactions. Early identification and management are essential to ensure safe use of anti–PD-1/PD-L1 treatments. Evaluat...
Creatine has little effect on contractile function, whereas Pi, rather than acidosis, appears to be the most important cause of fatigue during high-intensity exercise.48 Increased Pi substantially impairs myofibrillar performance, decreases SR Ca2+ release and therefore contributes to the decreased ...
The diagnosis of sickle cell nephropathy is made by detecting abnormalities such as albuminuria, hematuria or CKD rather than by distinct diagnostic criteria in SCD, which have not been developed. Traditional markers of kidney function such as serum creatinine and eGFR should be interpreted with cauti...
Imatinib, a common protein kinase inhibitor, has been developed and approved for the treatment of malignant tumors. Some studies have shown that imatinib also has immunosuppressive and anti-inflammatory effects and can be applied to autoimmune diseases, Alzheimer’s disease, Parkinson's disease and ot...
activation of the polyol pathway, and protein kinase C (PKC) activity [17]. These processes collectively contribute to peripheral nerve damage by impairing axonal transport and inducing axonal degeneration [18]. Excessive oxidative stress and accumulation of harmful by-products like sorbitol and fructos...
As revealed by a previous study, oral supplementation of RES (10 mg/day) for 4 weeks obviously improved insulin resistance and renal function in patients with diabetes [14]. Meanwhile, the urine albumin/creatinine ratio was remarkably reduced in diabetes patients who were treated with RES (500 ...
a comprehensive strategy is proposed to fully utilize both the ferroptotic vulnerability of PDAC to potently irritate anti-tumor immunity and the desmoplasia-associated focal adhesion kinase (FAK) to wholly improve the immunosuppressive microenvironment via sustained release of drugs in an injectable hydro...