We previously demonstrated that high expression of BMI1 together with loss-of-function of the ATP-dependent chromatin remodeller Chromodomain-Helicase-DNA-binding protein 7 (CHD7) cooperates in inducing MB formation when glutamatergic progenitor cells, expressing the proneural transcription factor Math1,...
The addition of the cyclin dependent kinase inhibitor (CDKi) dinaciclib to Poly-(ADP-ribose) polymerase inhibitor (PARPi) therapy is a strategy to overcome resistance to PARPi in tumors that exhibit homologous recombination (HR) deficiencies as well as t
Fibroblast growth factor receptors in cancer: genetic alterations, diagnostics, therapeutic targets and mechanisms of resistance Article Open access 03 December 2020 Efficacy of futibatinib, an irreversible fibroblast growth factor receptor inhibitor, in FGFR-altered breast cancer Article Open access ...
Expression characteristics, immune signatures, and prognostic value of the KIF family members identified across cancers Abstract: Aim:The overexpression of Kinesin superfamily proteins (KIFs) has been increasingly recognized as a critical factor associated with unfavorable...MORE ...
Body mass index in patients with moderate-to-severe psoriasis in Spain and its impact as an independent risk factor for therapy withdrawal: results of the Biobadaderm Registry. J Eur Acad Dermatol Venereol. 2014;28(7):907–14. https://doi.org/10.1111/JDV.12208. Article CAS PubMed Google...
In NSCLC patients, the activating mutations in the epidermal growth factor receptor (EGFR) are key drivers that occur in approximately 10–15% of Caucasians and 30–40% of East Asians [4,5]. In the past 20 years, more comprehensive studies and molecular understanding of the pathology of ...
Importantly, the activities of pro-inflammatory transcription factors, such as nuclear factor (NF)-κB, inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)− 2, can be reduced in the absence of CDK enzymatic activity [8], [9], [12], [13]. The potential to target CDKs and...
Antimicrobial hybrid peptide Lf-KR exhibits increased permeabilization and depolarization of microbial membranes, the ability to substantially impair expression and production of pro-inflammatory cytokines (nitric oxide and tumor necrosis factor‐α) in LPS-stimulated mouse macrophages and a powerful ...
Herein we report a randomized, double-blind, placebo-controlled, multiple-dose trial of a first-in-class pan-phosphodiesterase inhibitor ZSP1601 in 36 NAFLD patients (NCT04140123). There were three cohorts. Each cohort included twelve patients, nine of whom received ZSP1601 50 mg once daily,...
members of the Clostridia class in the distal GI tract and is the preferred energy substrate for colonic epithelial cells5. It strengthens gut barrier function by stabilizing hypoxia-inducible factor and maintains epithelial tight junctions23. To mediate its immunomodulatory functions, butyrate acts via...