The primary outcomes were the safety and tolerability of ZSP1601. A total of 27 (27/36, 75%) patients experienced at least one treatment-emergent adverse event (TEAE). Most TEAEs were mild to moderate. There was no Serious Adverse Event. Diarrhea, transiently elevated creatinine and adaptive ...
Diagnosis was suspected upon elevated urinary creatine/creatinine (except in one of the female patients) and on a markedly decreased creatine peak on magnetic resonance spectroscopy (MRS). Diagnosis was confirmed by molecular analysis that identified four novel mutations not reported so far, including ...
T cell activity had an inverse relation with age and poor activity was characterized by worse outcome in males, but not in females. Higher innate immune cytokines in female patients were associated with worse disease progression, but not in male patients. CCL5 and CXCL10 were more elevated in...
An improvement of the hepatic inflammatory process and reduction in the plasma levels of creatinine and uric acid were also observed. Uric acid is known to play a role in the development of liver steatosis; thus, its reduction was beneficial. It is important to note that CMA therapy is ...
aminotransferase [AST]>40 U/L, and elevated creatinine levels) based on a priori plausibility, documented associations with death or hydroxychloroquine administration from previous studies, bivariate associations within our data, ruling out collinearity using condition indices, and missingness of less than...
The mean age of the 8862 study participants was 61.0 ± 10.0 years, and 79.7% were men. The optimal cut point for the TyG index in patients with TVD was identified to be 9.51 (see Methods and Additional file 1: Fig. S1). Levels above this cutoff value were considered elevated....
The overall response rate was 40% (12/30; 95% confidence limits, 23-58%), with a median survival of 8 months. Vomiting was observed in 37% of patients; elevated serum creatinine levels (> 1.5 mg/dl), in 7%; leukopenia (< 3,000/mm3), in 39%; thrombocytopenia (< 70,000/mm3), ...
Results Elevated CPK levels were recorded in only five patients during treatment period. Maximum serum CPK values recorded for each patient ranged between 292 and 569 IU/l. Only one patient out of five had myalgia and four patients were completely asymptomatic. Conclusions In conclusion, marked ...
Aims'Worsening renal function' (WRF) and 'improvement in renal function' (IRF) monitored by changes in serum creatinine are frequently encountered during treatment of acute decompensated heart failure (ADHF). We sought to establish the important haemodynamic determinants of alterations in serum creatinin...
Table 2. Summary of the nationwide survey of IgA nephropathy in Japan (Ministry of Health, Labor and Welfare, Japan, 2005) Predictive factors after 10 y Male Under 30 y old Diastolic hypertension Heavy proteinuria Mild hematuria Low serum albumin Elevated serum creatinine Impaired renal histopatholog...