Human type 1 diabetes mellitus occurs due to chronic inflammation with lymphocytic infiltration and (usually) the presence of antibodies against insulin and characteristic islet cell proteins (e.g., GAD). This autoimmune process destroys the islets of Langerhans (including the beta cells) leading to...
Diabetes mellitus type 1 is a form of diabetes mellitus that results from the autoimmune destruction of insulin-producing beta cells in the pancreas. The current gold standard therapy for pancreas transplantation has limitations because of the long list of waiting patients and the limited supply of ...
Diabetes mellitus is the most common metabolic disorder, which occurs in two forms: Type1 diabetes (juvenile or insulin-dependent diabetes mellitus) and Type2 diabetes (adult or noninsulin-dependent diabetes mellitus). Type1 diabetes mellitus is a T-cell-mediated, organ-specific autoimmune disorder...
Stem cells in the treatment of diabetes mellitus - Focus on mesenchymal stem cells. Diabetes mellitus type 1 and type 2 have become a global epidemic with dramatically increasing incidences. Poorly controlled diabetes is associated with se... G Pth,N Perakakis,CS Mantzoros,... - Metabolism 被...
Stem cells in the treatment of diabetes. Ann Med. 37, 513- 520.Stem cells in the treatment of diabetes[J] . Timo Otonkoski,Ru Gao,Karolina Lundin.Annals of Medicine . 2005 (7)Otonkoski T,Gao R,Lundin K.Stem cells in the treat-ment of diabetes. Annals of Medicine . 2005...
The therapy aims to replace the insulin-producingbeta cellsthat people with type 1 diabetes lack. Dubbed VC-02, the small medical implant contains millions of lab-grown pancreatic islet cells, including beta cells, that originate from a line of pluripotent stem cells. ...
ChinaType 1 diabetes mellitus (T1DM) is an autoimmune disease that attacks pancreatic b-cells,leading to the destruction of insulitis-related islet b-cells. Islet b-cell transplantation has beenproven as a curative measure in T1DM. However, a logarithmic increase in the globalpopulationwithdiabetes...
This review aims to discuss recent progress in the study of adult pancreatic stem or progenitor cells and to suggest future directions in this field. 展开 关键词: Adult Stem Cells Diabetes Mellitus Type 1 Islets of Langerhans Transplantation 胰岛移植 ...
结论摇脐血干细胞改善1型糖尿病小鼠的症 状,降低血糖,改善小鼠胰岛功能及靶器官形态结构,并且具 有上调PDX鄄1及MafA蛋白水平的作用,脐血干细胞对1型 糖尿病小鼠具有一定的治疗效应。 关键词摇脐血干细胞;糖尿病;胰十二指肠同源盒1;肌腱膜 纤维肉瘤癌基因同源物A基因 中图分类号摇R329;R587.1 文献标志码A文章...
Liver stem cell-derived h-cell surrogates for treatment of type 1 diabetes B Consistent with the common embryonic origin of liver and pancreas as well the similar glucose-sensing systems in hepatocytes and pancreatic h-cells, it sho... LJ Yang 被引量: 0发表: 0年 Cellular engineering and ...