In treatment-naïve patients, objective response rate (“ORR”) was 62.1%, disease control rate (“DCR”) was 92.0% and median duration of response (“DoR”) was 12.5 months, as assessed by an independent review committee. Median progression free survival (“PFS”) was 13.7 mont...
One third (20% to 30%) of patients suffering from hypertension show increased blood pressure resistant to treatment. This resistance often has multifactorial causes, like therapeutic inertia and inappropriate medication but also poor patient adherence. E
(SVR) in patients with detectable ribonucleic acid (RNA) of hepatitis C virus (HCV) at the end of treatment (ET) with direct-acting antivirals (DAA), find how this is affected by the type of regimen, and how patients experiencing this differed from non-responders with detectable HCV RNA ...
8 Recently, in the FLAURA trial,9 osimertinib was compared with first-generation EGFR-TKIs in treatment-naive patients with advanced NSCLC and EGFR mutation.9 Median PFS was superior with osimertinib (18.9 months vs 10.2 months with the first-generation EGFR-TKIs erlotinib and gefitinib). Based ...
The regulatory dataset [consisted of] patients who had pathologically confirmed ROS1-positive, NSCLC with no other drivers. [They were] either TKI naive, meaning they never had received crizotinib or entrectinib, or had progressed on a prior TKI. The drug was given orally as ...
Design, Setting, and Participants This multicenter, single-arm, open-label, phase 2 nonrandomized controlled trial (Atezolizumab Plus Bevacizumab in First-Line NSCLC Patients [TELMA]) included treatment-naive patients aged 18 years or older with confirmed stage IIIB-IV nonsquamous NSCLC with TMB of...
a. (left) UMAP of all barcoded treatment-naive cells. Total 16,432 cells (8,420 split A and 8,012 cells in split B) are colored by clusters determined using Seurat’s FindClusters command at a resolution of 0.6 (i.e. “Seurat clusters, resolution = 0.6”). (right) On the UMAP, ...
Part of it is us understanding that naive patients, that’s the more moderate patient where you have a lot of options, where you’re not rushed for speed, all of these therapies do very well, and within 2 weeks you’re going to see an effect. Now, it won’t be as big as it ...
(GZ, meaning that HBV DNA and ALT levels do not fall into the same phase, n = 58). Patients in each phase were segregated into 2 groups with either active or inactive NK cell cytokine function based on the individual estimates derived from the nomogram. Table3showed the characteristics...
Feature Meaning Importance Std. Dev. BankDetailsAdded This is a binary “yes/no” feature representing whether patients have their bank details added to Nikshay, signifying an increased likelihood of receiving monthly monetary government incentives for better nutrition during the TB treatment. 0.105 0.0...