It would be helpful if this was discussed in the upcoming HFpEF guidelines, especially for use in patients who cannot afford or tolerate the new HFpEF medications.doi:10.1016/j.amjmed.2024.09.027Daniel M. Gelfman MD, FACC, FACPElsevier Inc.American Journal of Medicine...
To date, no treatment has been shown to reduce clinical events including CV and all-cause mortality in HFpEF. For such reason, guidelines merely recommend diuretics for fluid removal and symptoms relief (eg, edema),25 and management of associated comorbidities (eg, hypertension, obesity, chronic ...
Iron, as an essential micronutrient, is required for the metabolism in every cell of the human body, and ID is considered as a contributor of the deteriorating CV function during HF and as a marker of poor prognosis. Accordingly, current guidelines included clinical recommendations for iron ...
Heart failure with preserved ejection fraction (HFpEF) is an important yet under-recognized aspect of cancer therapy-related cardiac toxicity, described in a wide array of cancer therapeutics including BTK inhibitors, CAR-T therapies, and hematopoietic stem cell tr...
under-representation has been a limitation in conducting meaningful subgroup analysis. Subgroups that are markedly imbalanced may lack the statistical power required to detect treatment heterogeneity. The limitations of testing for interaction are also worth considering. Despite these limitations, evidence fro...
It has taken decades to agree on the term HFpEF in international guidelines. In 2008, the European Society of Cardiology (ESC) finally chose to use this term instead of “diastolic HF”, whose use has largely been abandoned over the following years. HFpEF is different from the prototypical ...
Tab.2 Recommendations for ARNI in heart failure guidelines from different country 表2 各国心衰指南对于ARNI的推荐要点 新指南提醒服用ACEI/ARB的患者,转为ARNI治疗前血压需稳定,并应停用ACEI 36 h,因脑啡肽酶抑制药和ACEI联用会明显增加血管性水肿的发生风险。在未使用ACEI或ARB的有症状HFrEF患者中,如血压能够...
(HFPEF). Patients who have heart failure but with a normal left ventricular ejection fraction; that is, above 40–50% (there is no consensus for the cut-off). Neurohumoral profile A decrease in cardiac pump function that is associated with a neurohumoral response, which is characterized by ...
Valve disease accounts for 10% and cardiomyopathies, usually dilated cardiomyopathy, for another 10% [1], [2]. Other causes are less common. Aetiology of heart failure with preserved ejection fraction (HFPEF) is different. Most common cause is hypertension, especially in elderly population, ...
Heart failure with preserved ejection fraction (HFpEF) is a common and difficult-to-treat heart disease. Approximately half of patients with heart failure suffer from this form, and mortality is between 5% and 7% per year. Previous therapeutic trials for the treatment of HFpEF have been disappoint...