When prescribing medications for gout one has to be mindful of the presence of comorbidities commonly affecting gout patients that may affect drug safety and efficacy, especially in the elderly and in patients treated with multiple drugs. The benefits of gout drugs, usually, outweigh their safety ...
Introduction: Gout is a rheumatologic condition associated with elevated serum uric acid levels and deposition of monosodium urate crystals in joints and soft tissues. The xanthine oxidase inhibitor, allopurinol, has historically been the principle agent utilized for reducing elevated uric acid levels and...
For most people with gout, dietary restrictions play a limited role in preventing gout attacks. However, you should avoid any foods that seem to trigger gout attacks. A heart-healthy diet such as the Mediterranean diet may reduce the risk of gout in some people.Treatment...
Treatment of the acute phase of pseudogout is identical to that of acute gout. In patients with idiopathic pseudogout, a deterrent regimen of colchicine may be used. If an underlying metabolic problem is responsible for pseudogout, addressing the underlying problem may result in cure of the arth...
BackgroundGout is a relatively common condition with low adherence to urate-lowering therapy (ULT) which leads to frequent flares and disability. To improve patient care the European League Against Rheumatism (EULAR) developed evidence-based recommendations for treatment of gout.ObjectivesAssess adherence...
More particularly the invention relates to new sulfonamide URAT-1 inhibitors of formula (I): (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined in the description. URAT-1 inhibitors are potentially useful in the treatment of a wide range of...
2011 Recommendations for the Diagnosis and Management of Gout and Hyperuricemia Gout is a major health problem in the United States; it affects 8.3 million people, which is approximately 4% of the adult population. Gout is most often d... M Hamburger,HSB Baraf,TC Adamson,... - 《Postgradu...
(1834–1900) was giving longitudinally lithium carbonate to patients with periodic depression. The rationale for using lithium was a concept of depression as “uric acid diathesis” (gout of the brain) (Lange,1886). Previously, lithium was introduced to treat gout by a British physician, Alfred...
However, the reported clinical effects vary. Objectives In this study, we reviewed and analyzed a large number of randomized controlled clinical trials to systematically assess the clinical efficacy and adverse reactions of Chinese herbal decoctions for treating gout. Methods We performed a comprehensive...
The FDA approval of febuxostat for the treatment of hyperuricemia in gout has been a significant step forward. Since its approval in 2009, febuxostat has... HK Grewal,JR Martinez,LR Espinoza - 《Expert Opinion on Drug Metabolism & Toxicology》 被引量: 42发表: 2014年 Febuxostat for treatment ...