Primary sclerosing cholangitis (PSC) is a rare disease of stricturing and destruction of the biliary tree with a complex genetic and environmental etiology. Most patients have co-occurring inflammatory bowel disease. Children generally present with uncomplicated disease, but undergo a variable progression...
studied medical treatment for primary sclerosing cholangitis; pilot studies suggest a possible role for tacrolimus and silymarin, however further studies are ... J Rl,Maggs,W Roger,... - 《Current Opinion in Gastroenterology》 被引量: 233发表: 2008年 Downregulation of the hepatocellular organic ani...
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown etiology. Despite advances in understanding the pathophysiology underlying this disorder, no effective medical therapy has been identified for halting disease progression. The aim of this investigation was to determine th...
Primary sclerosing cholangitis (PSC) is a chronic cholestatic syndrome of unknown etiology frequently associated with inflammatory bowel disease and characterized by diffuse inflammation and fibrosis of the intra and/or extrahepatic bile ducts. Recent studies seem to favor autoimmunity in the context of ...
Promising results have been reported for the role of antibiotic treatment in management of AC and PSC; however, immunosuppressive drugs have also rendered clinical responses in IAC. With respect to the high rate of complications, surgical interventions in patients with cholangitis are generally ...
OBJECTIVE: There is no effective therapy for patients with primary sclerosing cholangitis (PSC). Rats with experimental small bowel bacterial overgrowth develop hepatobiliary injury similar to PSC. The hepatobiliary injury results from peptidoglycan-polysaccharide–mediated activation of Kupffer cells, release...
High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis. Hepatology. 2009;50(3):808–14.•• Lindor KD, Kowdley KV, Luketic VA, et al. High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis. Hepatology 2009;50:808–14. A randomized, ...
5 In a broad classification system, cholangitis cases can be divided into three main categories, including primary sclerosing cholangitis (PSC), secondary cholangitis, and immune cholangitis.6 PSC is a serious disorder with yet unknown etiology; however, a role has been proposed for immune ...
Objectives:Treatment for primary sclerosing cholangitis(PBC),includes administration of ursodeoxycholic acid(UDCA)alone,or combination with metronidazole(MTZ)or mycophenolate mofetil(MMF),respectively.However,to date the optimum regimen ... 郑明华 - 浙江临床研究大会暨浙江省临床流行病学与循证医学学术年会 被...
High dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis Ursodeoxycholic acid (UDCA), a hydrophilic bile acid, is the most promising treatment option because of its benign side effect profile and documented ... MG Silveira,KD Lindor - 《Current Gastroenterology Reports》 被引...