In particular, for the treatment of childhood acute lymphoblastic leukemia, it had significant effect.MTX competitively inhibits dihydrofolate reductase (DHFR), an enzyme that participates in the tetrahydrofolate synthesis so as to inhibit purine synthesis. In addition, its downstream metabolite ...
Acute lymphoblastic leukemia (ALL), the most common type of cancer in children, is a heterogeneous disease in which many genetic lesions result in the development of multiple biologic subtypes. Today, with intensive multiagent chemotherapy, most children who have ALL are cured. The many national ...
Generation of functional dendritic cells for potential use in the treatment of acute lymphoblastic leukemia . Cancer Immunol Immunother ( 2002 ) 51 : 72Pospisilova D,Borovickova J,Polouckova A,et al.Generation of functional dendritic cells for potential use in the treatment of acute lymphoblastic ...
The excellent progress which has been made during the last 3 decades in the treatment of acute lymphoblastic leukemia (ALL) in children is well known, and it appears that about half of children with ALL are now probably being cured with the best therapeutic programs [1–4]. Using the same ...
A team of researchers at Case Western Reserve University School of Medicine has developed the first "theranostic" agent for the treatment of acute lymphoblastic leukemia (ALL). ALL is the most common type of childhood cancer diagnosed in approximately 5,000 new cases each year in the United ...
A team of researchers at Case Western Reserve University School of Medicine has developed the first "theranostic" agent for the treatment of acute lymphoblastic leukemia (ALL). ALL is the most common type of childhood cancer diagnosed in approximately 5,000 new cases each year in the United Stat...
Their median age was 27.5 years; 73% had B-lineage acute lymphoblastic leukemia (ALL) and 22% had T-lineage disease; 18% showed associated myeloid markers; 47 of 216 analyzed patients (22%) had Philadelphia chromosome–positive ALL. Response to PDN pretreatment was observed in 65% of cases...
If you are one of the authors, claim this publication so you can create a plain language summary to help more people find, understand and use it. Read the Original This page is a summary of:Blinatumomab for the treatment of acute lymphoblastic leukemia, Investigational New Drugs, September 201...
Dr. Robert Kreitman:When a patient gets diagnosed with hairy cell leukemia for the first time but doesn't need to be treated, that's called watch-and-wait. You just watch and you wait until the counts get bad enough or the spleen maybe gets big enough that causes symptoms and there's...
Peripheral blood haploidentical hematopoietic stem cell transplantation for treatment of acute lymphoblastic leukemia in adults: monitoring minimal residua... BACKGROUND: Recurrence of acute leukemia after hematopoietic stem cell transplantation is one of the major problems affecting the long-term survival of...