The introduction of the iron-chelator deferoxamine in the treatment of acute iron poisoning and various chronic iron overload states such as beta-thalassaemia major has dramatically improved the prognosis of patients affected. The outcome of long-term treatment, however, heavily relies on patient ...
A number of human disorders are related to chronic iron overload, either of genetic or acquired origin. The multi-organ damage produced by iron excess leads, in adults and in children, to severe clinical consequences, affecting both quality of life and life expectancy. The diagnosis is increasin...
A comparative study of deferasirox and deferiprone in the treatment of iron overload in patients with myelodysplastic syndromes[J].Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis 2013,12(12).A comparative study of deferasirox and deferiprone in the treatment of iron over...
Development of iron chelators to treat iron overload disease and their use as experimental tools to probe intracellular iron metabolism The development of an orally effective iron (Fe) chelator for the treatment of Fe overload diseases such as -thalassemia has been a difficult challenge. Ev... ...
The dosage and the route of administration (IV, IM, SC) were adapted to the amount of iron transfused and to the nature of the disease. The serum ferritin level was considered as the indicator of the iron overload. Comparisons were established between the quantities of iron transfused, ...
(for example, 60gram of alcohol or four glasses of wine or beer daily) was shown to increase the risk of liver cirrhosis by nine-fold in patients with hemochromatosis. Alcohol can also promote the absorption of iron from the intestines, resulting in further iron overload. Occasional social ...
To see if they could protect the vessels, the team tested a drug called deferoxamine. The drug is used to treat iron overload, which can happen for example when a person receives multiple blood transfusions. Deferoxamine has also been used in the treatment of myelodysplasia, a disease related...
and it is closely related to the pathophysiological process of ischemic stroke. Iron overload, reactive oxygen species accumulation, lipid peroxidation, and glutamate accumulation associated with ferroptosis are all present in ischemic stroke. This article focuses on describing the relationship between ferro...
Iron overloadis the result of many disorders and could lead per se to the development of organ damage and increased mortality. 铁超负荷是许多机能紊乱的结果,它能够导致自身器官的损害和死亡率的增加。 5) calcium overload 钙超负荷 6) overloading ...
Heart disease is the main cause of death in people who haveβ-Thalassemia Major in countries using safe,adequate blood supplies.Iron chelation therapy have led to dramatic improvement in survival of patients withβ-TM.The prevention and control of iron overload is an achievable goal to avoid or...