These vaccines are of proven efficacy in healthy adults and are effective in elderly people with and without medical conditions putting them at high risk of complications and death following influenza infection.However, vaccine coverage is patchy and often low, and outbreaks of influenza are not ...
In this study, we used messenger RNA (mRNA)-encoded Cas13a for mitigating influenza virus A and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in mice and hamsters, respectively. We designed CRISPR RNAs (crRNAs) specific for PB1 and highly conserved regions of PB2 of...
- 《Vaccine》 被引量: 604发表: 2007年 Health care worker beliefs about influenza vaccine and reasons for non﹙accination – a cross﹕ectional survey Aims and objectives. To identify reasons for poor uptake of influenza vaccine in healthcare workers. HS Canning,J Phillips,MS Allsup - 《...
This antibody was cloned from a single human plasmablast cell derived from a donor who had been vaccinated with a conventional inactivated influenza vaccine. PBMCs were isolated on day 7 after vaccination. The PBMCs were then stimulated in vitro with heterologous purified recombinant influenza HA, ...
Influenza is a major cause of morbidity and mortality in the elderly. Influenza vaccine is recommended for people aged 65 years and older and those in long term care. Currently only 30% of high risk persons are vaccinated. Vaccination generally stimulates an adequate immune response, is well tol...
(an influenza virus vaccine adjuvant) on enhancing immune responses and reducing antigen dose required for immunity [J]. PLoS One, 2017, 12(8): e0183720. doi: 10.1371/journal.pone.0183720 [15] Novel Coronavirus Pneumonia Emergency Response Epidemiology Team. The epidemiological characteristics of...
At present time, there is uncertainty regarding whether influenza-like illness in healthy adults is best managed by preventive efforts that use the trivalent influenza vaccine, administration of neuraminidase inhibitors at the onset of illness, or recommendation of supportive care alone at the onset of...
Influenza virns infections occur in epidemics, primarily during the winter. Serious pulmonary complications include primary viral pneumonia. Annual immunization with the influenza vaccine is recommended for high-risk individuals, including health care workers who might transmit influenza to such persons. Ant...
The ultimate aim of a therapeutic vaccine is to reshape the host immunity for eradicating a disease and establishing lasting memory. Therefore, therapeutic vaccines have been developed for the treatment of some infectious diseases and chronic noncommunicable diseases. Various technological strategies have ...
this study was to examine whether treatment with recombinant human erythropoietin (rHuEPO), previously found to be associated with a positive effect on cell-mediated immunity and humoral immunity (hepatitis B vaccine), is associated with an improved response to the seasonal influenza (flu) vaccine. ...