Recently, comprehensive research on NPs in the treatment of ocular diseases has shown a significant increasing annual trend, and NPs modified by active targeting ligands and NPs with stimulus-response functions have become the latest research hotspots. Typical components of therapeutic NPs are polymers ...
AAV has only shown minor side effects in gene therapy in dogs, and in a limited trial of gene therapy for muscular dystrophy in humans, and Kay claims that these problems are “technically solvable”. He also plans to use a different AAV serotype in his work. But he admits that “it's...
fate, impact and hazards of MPs and ARGs in WWTPs. This paper fills a gap in this regard. In our search, we used “microplastics”, “antibiotic resistance genes”, and “wastewater
Ticks like to attach to the soft, thin skin found in the folds of the body, like on the back of the knees and in the armpits. They can also be found on top of the head. People who perform tick checks after spending time outdoors must be aware of tick hotspots, or they are unlikel...
Testing for mutations can be done along the whole coding sequence or can be focused in the areas where mutations have been found to cluster. Particular hotspots of mutations occur at nucleotide positions 1624, 1633, 1636, and 3140 of PIK3CA coding sequence. PIK3CA mutations have been found in ...
“hypoendemic hotspots”6, where IVM treatment can cause serious adverse events (SAEs) whenL. loamicrofilaraemia is high (>30,000 mf/ml)7. In these areas, alternative strategies with drugs that are safe to use with loiasis will be required to meet elimination targets8. Alternative ‘test ...