Her2 overexpression has been linked with a more aggressive breast cancer phenotype and with decreased survival in patients with Her2-positive tumors. Trastuzumab and lapatinib are approved targeted agents for treatment of Her2-overexpressing breast cancer. The use of trastuzumab in this patient population...
Sara A. Hurvitz, MD, comments on her preferences for treating patients with HER2-positive metastatic breast cancer and shares her strategy for sequencing therapies.
HER2-positive breast cancer is a type of breast cancer that tests positive for a protein called human epidermal growth factor receptor 2 (HER2), which promotes the growth of cancer cells. Approximately one of every five breast cancers have a gene mutation in the cancer cells...
Cancer Network: Dr. Pegram, what are the current HER2 therapies available for treatment of women with HER2-positive breast cancer? Dr. Pegram: Since 1998, we have had trastuzumab, which has become the mainstay of HER2-targeted breast cancer therapies for both advanced ca...
This study evaluated by immunohistochemistry (IHC) immune cell response during neoadjuvant primary systemic therapy (PST) with trastuzumab in patients with HER2-positive primary breast cancer. In all, 23 patients with IHC 3+ primary breast cancer were tr
HER2-Positive Early Breast Cancer: Time for Ultimate De-Escalation? Simple Summary: In the quest for de-escalation strategies, the complete elimination of non-targeted cytotoxic chemotherapy is often considered the ultimate... N Tauber,C Cirkel,A Claussen,... - 《Cancers》 被引量: 0发表: 2024...
The UK has conditionally approved Enhertu® (trastuzumab deruxtecan) as a monotherapy for the treatment of unresectable or metastatic HER2 positive breast cancer based on Phase II trial results...
Trastuzumab emtansine (T-DM1) for the treatment of HER2-positive cancer with a focus on breast cancer. In: Phillips, G.L., ed. Antibody-Drug Conjugates and Immunotoxins. New York: Springer; 2013; p. 179-210... HS Rugo,IE Krop,YW Chu - Springer New York 被引量: 2发表: 2013年 Rea...
Breast Cancer: Targets and Therapy Dovepress open access to scientific and medical research Open Access Full Text Article Trastuzumab emtansine in the treatment of HER2-positive metastatic breast cancer in Japanese patients Review This article was published in the following Dove Press journal: Breast ...
New challenges and opportunities in the management of brain metastases in patients with ErbB2-positive metastatic breast cancer. The introduction of trastuzumab for the treatment of tumors that overexpress ErbB2 (also known as HER2) has contributed significantly to recent improvement... ME Melisko,M...