In addition, age seems to play a role in the onset of gout. Men typically develop gout between the ages of 30 and 50. Women, on the other hand, rarely develop symptoms until they are 50 and older. Very few cases of gout have been diagnosed in children and young adults. Product Review...
In addition, age seems to play a role in the onset of gout. Men typically develop gout between the ages of 30 and 50. Women, on the other hand, rarely develop symptoms until they are 50 and older. Very few cases of gout have been diagnosed in children and young adults. ...
Gout is the one of the most common forms of inflammatory arthritis in adults. As the incidence and prevalence of gout are increasing and many patients cannot tolerate or have contraindications to standard treatments, there is a need for new, more effective therapeutic agents. IL-1 is a proinfla...
The buildup of uric acid crystals in the joint cavity causes inflammation,gouty arthritis, or simply “gout.” Gout in its early stages usually occurs in only one joint, but sooner or later, gout can affect many joints and can often lead to swollen joints or, even worse, loss of function...
Gout is an often forgotten disease,1 despite being the most common inflammatory arthritis in adults in the Western world.2鈥 4 Lesinurad, a new urate-lowering therapy (ULT), is now approved for the treatment of gout in the USA and the European Union,5 ,6 and is in phase III programmes...
Gout is the most common inflammatory arthritis and occurs when hyperuricaemia, sustained elevation of serum urate levels resulting in supersaturation of body tissues with urate, leads to the formation and deposition of monosodium urate crystals in and ar
KRYSTEXXA®(pegloticase) is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments. KRYSTEXXA is not for use in people with too much uric acid in their bodies who do not have symptoms (asymptomatic hyperuricemia). ...
In clinical trials of adults with gout for whom target sUA levels could not achieved with allopurinol alone, lesinurad in combination with allopurinol nearly doubled the number of patients in whom the sUA target of <6 mg/dL at 6 months was achieved. It reduced the mean sUA level to <6 mg...
In 1960, Talbott and Terplan found that nearly all subjects with gout hadarteriosclerosis,glomerulosclerosisandinterstitial fibrosisin their kidneys. As many of these subjects also haduratecrystals in their tubules and interstitium, the disease was termed “gouty nephropathy”[10]. Unfortunately for this...
doi:10.1001/jamanetworkopen.2023.30885 Key Points Question What is the association between using sodium-glucose contransporter-2 inhibitors (SGLT2i) and the risk of recurrent gout flares among adults with gout and type 2 diabetes? Findings In this cohort study of 5931 patients with gout and type...