Suhail A. R. DoiDivision of Endocrinology and Metabolic Medicine, Mubarak Al Kabeer Hospital, Jabriya, KuwaitClinical EndocrinologyDoi SA. Treatment of euvolemic hyponatremia: sodium repletion or water depletion? Clin Endocrinol (Oxf) 2003;59:142....
Pulmonary edema may be due to either fluid overload or adult respiratory distress syndrome and can be minimized by keeping patients euvolemic. Acute renal failure is generally oliguric. With dialysis, renal function can be expected to return after a median of 4 days, although some patients may ...
Two vasopressin antagonists (‘vaptans’) are now in the market for the treatment of euvolemic (Europe) or euvolemic and hypervolemic (United States) hyponatremia: conivaptan for intravenous use and tolvaptan for oral application. Although their specificity and effectiveness are considered established,...
Euvolemic hyponatremia (SIADH) Fluid restriction of 500 mL/d below the 24-h urine volume (first-line treatment) Urea, vaptan, or demeclocycline (second-line treatment) Fluid restriction (first-line) Urea or loop diuretics + oral NaCl (second-line) Do not recommend vaptans Recommend against ...
The aim of this review is to present how to differentiate hypovolemic, euvolemic and hypervolemic hypernatremias, suggesting algorithms for practical management.doi:10.3109/14767058.2011.607667Marcialis, Maria AntoniettaDessi, AngelicaPintus, Maria Cristina...
Treatment depends on several factors, including the cause, overall volume status of the patient, severity of hyponatremic symptoms, and duration of hyponatremia at presentation. Vasopressin antagonists like tolvaptan seem promising for the treatment of euvolemic and hypervolemic hyponatremia in heart ...
1 Tolvaptan, which rids the body of excess free water, is indicated for patients with hypervolemic or euvolemic hyponatremia—including those with heart failure or SIADH—who have a sodium level less than 125 mEq/L, or a sodium level of less than 135 mEq/L with symptoms of ...
Pulmonary edema may be due to either fluid overload or adult respiratory distress syndrome and can be minimized by keeping patients euvolemic. Acute renal failure is generally oliguric. With dialysis, renal function can be expected to return after a median of 4 days, although some patients may ...
The present review considers the role of vasopressin receptor inhibitors (vaptans), focusing on lixivaptan, in the treatment of patients with euvolemic or hypervolemic hyponatremia. Lixivaptan is an oral selective V2 receptor inhibitor, which produces a significantly greater increase of serum sodium ...
Drug Administration for use in treating euvolemic and hypervolemic hyponatremia in hospitalized patients and lixivaptan and tolvaptan in the late stages of development, prudent use of these agents requires a thorough understanding of the clinical manifestations of hyponatremia to optimize therapeutic ...