The management of patients with amyloid heart disease is complex. Loop diuretics together with aldosterone antagonists represent the basis for influencing signs of congestion. In AL amyloidosis, high-dose chemotherapy followed by autologous stem cell transplantation is generally considered to be a front-...
For example, in Alzheimer's disease, a biopsy of brain tissue rarely is done. The biopsy could injure the brain and while the results might provide a diagnosis, it would be unlikely to change treatment (because there is no effective treatment for amyloid in the brain). When amyloidosis is ...
Amyloidosis, disease characterized by the deposition of an abnormal protein called amyloid in the connective tissues and organs of the body that inhibits normal functioning. Amyloid is a fibrous, insoluble protein-carbohydrate complex that forms when nor
EP: 1.Defining Heart Failure: HFpEF and HFrEF EP: 2.Diagnosis and Treatment Approaches in Heart Failure Now Viewing EP: 3.Historical Treatment Options in Heart Failure EP: 4.ARNIs for the Treatment of Heart Failure EP: 5.The Role of Ivabradine in Patients with Heart Failure EP: 6.Safety...
- 《Circulation An Official Journal of the American Heart Association》 被引量: 0发表: 2019年 Treatment of transthyretin familial amyloid polyneuropathy with tafamidis: a case report INTRODUCTION: Familial amyloid polyneuropathy (FAP) is a rare hereditary disorder caused by mutations in the ...
Amyloid beta protein (Abeta) in Alzheimer's disease induces oxidative stress through several mechanisms, including stimulation of nitric oxide synthase (NO... Abbas K. Ali, William A. Banks, Vijaya B. Kumar, Gul N. Shah, Jessica L. Lynch, Susan A. Farr, Melissa A. Fleegal-DeMotta and...
Familial (or hereditary) amyloidosis.This is a rare form passed down through families. It often affects the liver, nerves, heart, and kidneys. Many genetic defects are linked to a higher chance of amyloid disease. For example, an abnormal protein such as transthyretin (TTR) is usually the ca...
heart diseasephysical diagnosis/cardiovasculartreatmentTransthyretin鈥恟elated amyloidosis (ATTR) is a subgroup of amyloidosis that results from extracellular misassembled and toxic amyloid deposits affecting multiple organ systems, and cardiac tissues in particular. Because ATTR often presents as heart failure...
(TTR), a liver protein involved in the transport of thyroxine and retinol63. The gene mutations cause TTR protein instability leading to its dissociation and the accumulation of toxic and insoluble aggregates of amyloid fibrils in multiple sites including the heart, eyes, peripheral nerves, and ...
摘要: The invention provides a transgenic mouse that is a model for heart muscle disease and heart failure. Also provided are methods of using the transgenic mouse model to study heart muscle disease and heart failure and conditions and treatments related thereto....