Pharmacokinetics Trimethoprim is rapidly and almost completely ab- sorbed from the gastrointestinal tract and peak concen- trations in the circulation occur about 1 to 4 hours after an oral dose; peak plasma concentrations of about 1 microgram/mL have been reported after a single dose of 100 mg...
After 1 to 3 days, the dose should be re- duced to the minimum effective amount, which may be as little as 200 mg daily; treatment should be given for the shortest peri- od possible, up to a usual maximum of 1 week. Reduced doses are recommended in elderly patients. In some ...
Randomized trial of high loading dose of clopidogrel for reduction of periprocedural myocardial infarction in patients undergoing coronary intervention: Results from the armyda-2 (antiplatelet therapy for reduction of myocardial damage during angioplasty) study. Circulation 2005, 111, 2099–2106. [PubMed...
We discuss the limitations of the first chemotherapeutic drugs as a motivation for the establishment of combined drug treatment as standard practice in spite of concerns about frequent severe, dose limiting toxicities. Next, we introduce the development of targeted treatment as a concept for ...
For example, Fe2+/PMS treatment have proved to significantly mitigate fouling caused by NOM, obtaining a fouling control performance slightly higher than single coagulation with the same iron dose [129]. Moreover, in another study, pretreatments with Fe2+/PMS significantly increased the efficiency ...