Further, Lu et al,5 demonstrated that naturally selected 7CAR (NS7CAR) T cells from bulk T cells were able to overcome major fratricide by minimizing accessible CD7 epitopes.5 Another notable target is CD70. For example, Barta highlighted an allogeneic product that disrupts expression to ...
They are naturally arising, then they are modified into a cancer therapy. We are seeing a cancer drug being made from a person's own cells that did not cause disease in that person before, and did not cause toxicity in that person before. So, if our modifications don't go on to ...
strains. This review discusses recently identified naturally occurring sulfur-containing compounds, including glucosinolates and organosulfur, and their therapeutic potential for treating metabolic disorders and infectious diseases. This is a preview of subscription content,log in via an institutionto check acc...
Childhood Paraganglioma; Paranasal Sinus and Nasal Cavity Cancer; Parathyroid Cancer; Penile Cancer; Pharyngeal Cancer; Pheochromocytoma; Childhood Pheochromocytoma; Pituitary Tumor; Plasma Cell Neoplasm/Multiple Myeloma; Pleuropulmonary Blastoma; Pregnancy and Breast Cancer; Primary Central Nervous System (CNS...
In some embodiments, the antibody according to the invention is a single domain antibody. The term “single domain antibody” (sdAb) or “VHH” refers to the single heavy chain variable domain of antibodies of the type that can be found in Camelid mammals which are naturally devoid of light ...
Peptides and proteins are both polymers of amino acid residues; we may use the term “peptide” to refer to a short polymer (e.g., a trimer) or to a fragment of a full-length, naturally occurring protein. The first agent or the second agent, regardless of its intended use, can be ...
Such excipients are suspending agents, for example sodium carboxymethyl cellulose, methyl cellulose, hydroxy-propylmethylcellulose, sodium alginate, polyvinyl-pyrrolidone, gum tragacanth and gum acacia; dispersing or wetting agents may be a naturally-occurring phosphatide, for example lecithin, or ...
The term “peptide” includes two or more amino acids covalently attached through a peptide bond Amino acids which can be used in peptide carrier molecules include those naturally occurring amino acids found in proteins such as glycine, alanine, valine, cysteine, leucine, isoleucine, serine, ...
As used herein, the term Fc includes variants of naturally occurring sequences. An immunoglobulin light or heavy chain variable region consists of a framework region interrupted by three hypervariable regions. The term “hypervariable region,” also referred to herein as “complementarity determining ...
A protein, peptide, or polypeptide may be just a fragment of a naturally occurring protein or peptide. A protein, peptide, or polypeptide may be naturally occurring, recombinant, or synthetic, or any combination thereof. A peptide that is “derived from” a protein (e.g., a peptide derived...