This method was naturally used by bacteria as a defense mechanism in their adaptive immune system. Genes isolated from these bacteria was studied by the researchers, which brings the idea of using CRISPR to treat genetic diseases and carcinogenesis. CRISPR/Cas9 system is composed of 2 components ...
Peptides are naturally occurring bioactive chemical tools that can mimic a protein surface, and that possess high selectivity, good efficacy, and low toxicity [18], [19]. However, linear peptides suffer from limitations such as poor plasma stability and low oral bioavailability [20]. By introduc...
Disclosed herein are methods and compositions for treating multiple myeloma, and for enhancing antibody-dependent cellular toxicity (ADCC). Specifically, disclosed herein are methods of using antagonists of the aryl hydrocarbon receptor (AHR) to treat multiple myeloma and enhance ADCC. Also specifically ...
In one aspect, solutions or suspensions used for parenteral, intradermal, subcutaneous, or topical application can include any of the following components: a sterile diluent such as water for injection, saline solution, fixed oil, a naturally occurring vegetable oil such as sesame oil, coconut oil,...
Hideshima et al., 2000, “Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy,” Blood 96(9):2943-2950. Offidani et al., 2003, Thalidomide plus oral melphalan for advanced multiple myeloma: a phase II study. Haematologica. Dec. 2003;...
Amino acids which can be used in peptide carrier molecules include those naturally occurring amino acids found in proteins such as glycine, alanine, valine, cysteine, leucine, isoleucine, serine, threonine, methionine, glutamic acid, aspartic acid, glutamine, asparagine, lysine, arginine, proline, ...
Receptors may be naturally-occurring or synthetic molecules. Receptors may also be referred to in the art as anti-ligands. As used herein, the receptor and anti-ligand are interchangeable. Receptors can be used in their unaltered state or as aggregates with other species. Receptors may be ...
meant both the area adjacent to a section of bone or group of bones in need of treatment in a human or other organism in need thereof or a region inside the bone, including the site of a fracture or opening which occurs naturally or is intentionally made in the bone or group of bones...
naturally resistant to chemotherapeutic agents—they have various pumps (e.g., multidrug resistance protein pump) that efflux drugs, higher DNA repair capability, and have a slow rate of cell turnover (chemotherapeutic agents naturally target rapidly replicating cells). CSCs, being the mutated ...
The length of the oligonucleotide is at least 10 nucleotides and may be as long as the naturally-occurring BCL2L1 transcript. Preferably, the oligonucleotide is 19-25 nucleotides in length. Most preferably, the oligonucleotide is less than 75, 50, 25 nucleotides in length....