Trazodone for sleep disturbance during methadone maintenance: a double-blind, placebo-controlled trial. Drug Alcohol Depend. 2011;120:65-73.Stein MD, Kurth ME, Sharkey KM, Anderson BJ, Corso RP, Millman RP. Trazodone for sleep disturbance during methadone maintenance: a double-blind, placebo-...
trazodonehas the potential to have therapeutic effects on the initiation and maintenance of sleep.3Trazodoneis primarily metabolized throughCYP3A4andCYP2D6pathways and can have significant interactions with other agents that are associated with these livercytochrome systems.3Trazodone has oneactive ...
However, there is substantial evidence from placebo-controlled maintenance trials in adults with MDD that antidepressants delay the recurrence of depression. Monitor all antidepressant-treated patients for clinical worsening and emergence of suicidal thoughts and behaviors, especially during the initial few...
Sleep problems and insomnia are common, challenging to treat, and transcend specific diagnoses. Although trazodone is a popular choice, robust meta-analytic evidence is lacking. This systematic review and meta-analysis investigates the efficacy and safety of trazodone for sleep disturbances, reflecting r...
Once a satisfactory response has been obtained the dos- age may be gradually reduced for maintenance; some patients may continue to respond to 10 mg daily. Tranylcypromine should be withdrawn gradually to reduce the risk of withdrawal symptoms. Preparations BP 2008: Tranylcypromine Tablets. ...
The maintenance dose should be kept at the lowest effective level. Once the desired pharmacologic effects are achieved, the dosage may be gradually reduced. Dose may be adjusted depending on the patient’s response to the treatment. Treatment of Insomnia and Sleep Disorders ...
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Ninety-two percent found it helped with sleep onset, and 78% reported improvement with sleep maintenance. There was a significant correlation between the effectiveness in decreasing nightmares and improving sleep (r= .57, p < .005). The effective dose range of trazodone for 70% of patients ...
Neuromyelitis optica (NMO) is an autoimmune condition of the central nervous system, which is characterized by optic neuritis and longitudinal transverse myelitis.1,2 Its diagnosis is based on clin...
It has effects only on sleep onset, not maintenance of sleep, and accordingly its FDA-approved indication is for treating sleep-onset problems only. It is generally well-tolerated, with daytime sedation as the most common adverse effect. It is not a DEA-scheduled medication. Another non-DEA ...