Trazodone for sleep disturbance during methadone maintenance: a double-blind, placebo-controlled trial. Drug Alcohol Depend 2012;120:65e73.Stein MD, Kurth ME, Sharkey KM, Anderson BJ, Corso RP, Millman RP. Trazodone for sleep disturbance during methadone maintenance: a double-blind, placebo-...
However, there is substantial evidence from placebo-controlled maintenance trials in adults with MDD that antidepressants delay the recurrence of depression. Monitor all antidepressant-treated patients for clinical worsening and emergence of suicidal thoughts and behaviors, especially during the initial few...
Although trazodone is efficacious for sleep maintenance difficulties, its associated cognitive and motor impairments may provide a modest caveat to health-care providers. 展开 关键词: insomnia posturography short-term memory trazodone verbal learning ...
展开 关键词: Humans Sleep Disorders Sleep Initiation and Maintenance Disorders Priapism Substance-Related Disorders Trazodone Hypnotics and Sedatives Treatment Outcome Depressive Disorder Comorbidity DOI: 10.4088/JCP.v65n0605 被引量: 150 年份: 2004 收藏 引用 批量引用 报错 分享 全部...
With a Tmax of 1 to 2 hours and a T1/2 of 7 to 15 hours, trazodone has the potential to have therapeutic effects on the initiation and maintenance of sleep.3 Trazodone is primarily metabolized through CYP3A4 and CYP2D6 pathways and can have significant interactions with other agents that ...
0862 A unique case of severe sleep onset and maintenance insomnia following COVID-19 vaccination Many have attributed the rise of insomnia to pandemic-related stress, disturbance of circadian rhythm from home confinement, and worsening mental health. Conclusion To our knowledge, there have not been ...
The maintenance dose should be kept at the lowest effective level. Once the desired pharmacologic effects are achieved, the dosage may be gradually reduced. Dose may be adjusted depending on the patient’s response to the treatment. Treatment of Insomnia and Sleep Disorders ...
Once a satisfactory response has been obtained the dos- age may be gradually reduced for maintenance; some patients may continue to respond to 10 mg daily. Tranylcypromine should be withdrawn gradually to reduce the risk of withdrawal symptoms. Preparations BP 2008: Tranylcypromine Tablets. ...
Maintenance Treatment The efficacy of Oleptro for the maintenance treatment of MDD has not been evaluated. While there is no body of evidence available to answer the question of how long a patient treated with Oleptro should continue the drug, it is generally recommended that treatment be conti...
sleep duration. It may improve sleep quality and continuity but has minor effects on sleep latency, efficiency, and daytime impairment. Trazodone is associated with adverse effects, necessitating a careful risk-benefit assessment. Limited data restrict generalizability, underscoring the need for more ...