Trazodone is extensively metabolized; less than 1% of an oral dose is excreted unchanged in the urine. Elimination In some patients trazodone may accumulate in the plasma. Protein Binding Trazodone is 89 to 95% protein bound in vitro at concentrations attained with therapeutic doses in humans....
During the first week this effect was significantly better for the single dose at night group. This early effect may be particularly useful in providing psychological encouragement to depressed patients at the onset of treatment. 展开 关键词: Humans Piperazines Trazodone Drug Administration Schedule ...
Trazodone dosage for dogs The recommended dose range is between 0.5 mg/kg to 3 mg/kg/day given orally. Give the drug 30 minutes before feeding your dog. Sometimes, you may increase the dosage to 6 mg/kg/day divided into two daily doses. Adjust the dose depending on your pet’s respon...
It globally increases serotonin levels by blocking presynaptic reuptake in humans4 and presumably in dogs and cats. Higher doses (see Recommended Starting Dose in Dogs) are typically required to achieve reuptake inhibition.4 The drug also readily antagonizes postsynaptic serotonin 2A and 2C receptor...
There are virtually no dose-response data for trazodone vis--vis sleep and, similarly, no available data on tolerance to its possible hypnotic effects. Areas of concern with its use include reports of significant dropout rates and induction of arrhythmias, primarily in patients with histories of ...
administration. This can be variable, however, as can duration of action so it is important to test the medication before the anticipated event so as to know what to expect. Often trazodone is given at a lower dose for a couple of days to reduce the potential for upset stomach side ...
Dosage Of Trazodone For Dogs The dosage of Trazodone will vary depending on the size and weight of your dog as well as the severity of its symptoms. Generally, vets will start with a low dose and increase it gradually until the desired effect is reached. The standard dosage for dogs is...
Trimethyltin is a neurotoxicant which produces a distinct pattern of neuronal cell death following peripheral administration of a single dose (8 mg/kg, i.p... CD Balaban,JPO Callaghan,ML Billingsle - 《Neuroscience》 被引量: 353发表: 1988年 Comparative Effects of Ethanol and Malnutrition on th...
The pharmacokinetic and some pharmacodynamic characteristics of a single oral dose of 100 mg trazodone were compared in young and elderly volunteers. The m... AJ Bayer,MS Pathy,SI Ankier - 《British Journal of Clinical Pharmacology》 被引量: 73发表: 1983年 Herb-drug interaction of silymarin or...
The aim of this study was to compare the plasma concentration of MCPP following single oral dose administration of trazodone and MCPP in humans. Trazodone (100 mg) and MCPP (40 mg) were administered to 11 normal volunteers (mean age 62.6 [plusmn] 2.4 years; 8 males, 3 females). ...