Dogs were administered trazodone (5 to 7.5 mg/kg PO Q12h) or placebo. [Correction added after first online publication on 14 October 2023. In the abstract (methods) section (57.5 mg/kg PO Q12h) changed as (5 to 7.5 mg/kg PO Q12h).] Buccal mucosal bleeding time (BMBT), ...
The drug works by increasing serotonin activity in the brain, which can have an adverse effect on coordination and balance. Colitis (Inflammation Of The Colon)Trazodone can cause colitis, which is an inflammation of the colon in dogs. This is due to its ability to disrupt the balance of ...
Adverse events associated with oral administration of trazodone in dogs and cats are typically mild and well-tolerated. Potential effects include1,2,6 Sedation Ataxia GI effects (eg, vomiting, diarrhea) Increase or decrease in appetite Agitation Tachycardia Behavioral disinhibition IV administration of ...
Adverse reactions reported include the following:[citation needed] 3.Drug Interactions (1).Trazodone (19794-93-5) may enhance the effects of alcohol, barbiturates and other CNS depressants; patients should be cautioned accordingly as trazodone with the combination of another CNS depressant, can ...
General adverse events The most commonly reported side effects included drowsiness, dry mouth, dizziness, and lightheadedness.[Ref] Nervous system Very common(10% or more): Drowsiness (up to 41%), dizziness (up to 28%), lightheadedness (up to 28%), headache (up to 20%) ...
Substantially increased plasma trazodone concentrations possible, with potential for adverse effects If used concomitantly, consider reduction in trazodone dosage Carbamazepine Substantially decreased plasma concentrations of trazodone and active metabolite, m-chlorophenylpiperazine Closely monitor during concomit...
Some adverse reactions have been reported in clinical studies that may be related to the use of Trazodone hydrochloride, such as akathisia, allergic reactions, anemia, gastric bloating, abnormal urination, sexual dysfunction and menstrual abnormalities. But it is seen in very few patients. ...