Other TRAV1-2− MR1-restricted T cell clones have been described (31) and one of these clones (D462-E4) carries the TRAV12-2/TRAJ39 paired with TRBV29-1/TRBJ01-05 gene. Interestingly, the D462-E4 T cell clone showed a distinct pattern of ligand and microbial recognition in ...
基因简称(symbol) TRAV1-1[HGNC][GeneCards][NCBI] 基因种类(locus group) other 同源简称(alias symbol) TRAV11|TCRAV1S1|TCRAV7S1 基因家族代码(gene_family_id) 371[HGNC][GenScript] omim代码 entrez码 28693[Vega] ensembl基因码 ENSG00000255569[Ensembl] ...
TCR ab CDR3 sequences and gene names of D462-E4 are shown, right. (d) BEAS2B cell line infected with mycobacteria and tested for their ability to stimulate T-cell clones in the presence of blocking antibodies or isotype by IFN-g ELISPOT assays, D462-E4, D481-F12 (TRAV1-2 þ ...
Here we describe microbe-reactive MR1-restricted T cells that do not express TRAV1-2. Functional analysis reveals that these cells, although less prevalent than those that express TRAV1-2, can be found in PBMC from all individuals. Among MR1-Ag tetramer-positive cells, 1–4% are TRAV1-2...