Further analyses of outcomes according to head AIS 3, 4 and 5 showed no significant difference in the seizure rate between the two groups: head AIS 3: 6.1% in the prophylaxis group versus 2.6% in the no-prophylaxis group, p=0.329; head AIS 4: 0 versus 2.7%, p=0.302; head AIS 5: ...
Retrospective analysis of phenytoin and levetiracetam for seizure prophylaxis after traumatic brain injuryD., VirantYoungR., AlexanderG., UmsteadR., SavoyMooreD., HimesM., NikolavskyM., DehoorneSmith
Seizure prophylaxis for 7 days recommended:-BZDs for active seizures-phenytoin/fosphenytoin: loading dose, then initiate maintenance dose-levetiracetam controversial-Keppra-no valproate (mortality) Hyperthermia -poorer outcomes-aggressive temp management: medications, cooling blankets-therapeutic hyperthermia ...
Levetiracetam versus Phenytoin as Seizure Prophylaxis in Severe Traumatic Brain Injury: 840METHODS: Under an institutional Investigational Use Policy, 32 consecutive TBI patients from November 6, 2006 to October 13, 2007 with admission GCS score of 3 to 8 received levetiracetam (1000 mg IV BID) ...
Poster 39 Examining Utilization of Seizure Prophylaxis after Traumatic Brain InjuryEmbryonic stem cellLiverOrganogenesisCardiomyocyteEndothelial cellRecent studies in the field of regenerative medicine have exploited the pluripotency of embryonic stem (ES) cells to generate a variety of cell lineages. However...
Post-traumatic seizuresSeizure prophylaxisAntiepileptic drugsIn the trauma intensive care setting, the delivery of adequate nutrition is a daily concern. Early enteral feeding is beneficial for multi-trauma patients and those with traumatic brain injury. Howeve...
Results: In this study, 100 patients with TBI met the inclusion criteria between January 2012 and June 2017, wherein 60 received seizure prophylaxis with phenytoin, and 40 with levetiracetam. The incidence of early post-traumatic seizure was 8%, without significant di...
Introduction: Administration of seizure prophylaxis is routinely provided by many clinicians after traumatic brain injury. The most recent guidelines from the Brain Trauma Foundation weakly recommend the practice and suggest provision of anti-epileptics only for the prevention of early-seizures. Pr...
Evaluation of Levetiracetam for Early Post-Traumatic Seizure Prophylaxis: A Level II Trauma Center Experiencedoi:10.21203/rs.3.rs-1075454/v1Timothy A AminSteven F NerenbergOsama A ElsawyJackie P Johnston
Phenytoin has been the anticonvulsant of choice for seizure prophylaxis in traumatic brain injury (TBI). However, a 2010 audit at our institution showed that 1 in 10 patients who were commenced on phenytoin for this indication were changed...